{"id":"W4411450735","doi":"10.1007/s00395-025-01124-x","title":"The innate immune receptor NLRX1 is a novel required modulator for mPTP opening: implications for cardioprotection","year":2025,"lang":"en","type":"article","venue":"Basic Research in Cardiology","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"HORIZON EUROPE European Innovation Council; HORIZON EUROPE Framework Programme; Horizon 2020 Framework Programme; Heinrich-Heine-Universität Düsseldorf; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Dutch Cardiovascular Alliance; ZonMw; National Natural Science Foundation of China; Boehringer Ingelheim Stiftung; Fondation Leducq; European Foundation for the Study of Diabetes","keywords":"MPTP; Cardioprotection; Mitochondrion; AMPK; Biology; Mitochondrial permeability transition pore; MFN2; Cell biology; Autophagy; Internal medicine; Endocrinology; Medicine; Ischemia; Phosphorylation; Programmed cell death; mitochondrial fusion; Apoptosis; Biochemistry; Protein kinase A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002404571,0.0003059346,0.0004124252,0.0001661177,0.0001721382,0.0004356291,0.0002235086,0.0004041286,0.00104797],"category_scores_gemma":[0.0001238198,0.00009358843,0.0003417787,0.00009328673,0.0003140144,0.0005471428,0.0002397703,0.0006037177,0.0003011424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002486129,"about_ca_system_score_gemma":0.0001433688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006971656,"about_ca_topic_score_gemma":0.00008267222,"domain_scores_codex":[0.9998877,0.0000183362,0.00001388407,0.00003718916,0.00002139548,0.00002158671],"domain_scores_gemma":[0.9998945,0.000009812857,0.00004778486,0.000007817987,0.00001365093,0.00002631472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000284286,0.00002413736,0.001005329,0.0001507393,0.0000143678,0.0003567231,0.00004016662,0.00008367356,0.9950062,0.0003415281,0.0001087344,0.002584103],"study_design_scores_gemma":[0.0001286292,0.001290507,0.0499489,0.0001261106,0.0001837118,0.006282412,0.0003916895,0.003354391,0.917141,0.001810471,0.01930243,0.00003973032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9554843,0.03118012,0.009088654,0.001808899,0.0001154055,0.0000417534,0.0003337366,0.0001250166,0.001822211],"genre_scores_gemma":[0.9872811,0.006657264,0.003265199,0.000269838,0.0001003368,0.00003091355,0.0003826231,0.00001698752,0.001995742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00104797,"threshold_uncertainty_score":0.003505826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09999927257416788,"score_gpt":0.4263176097019594,"score_spread":0.3263183371277916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}