{"id":"W4411453285","doi":"10.3390/pathogens14060606","title":"Characterization of the Diversity in Host Range of an Extensively Drug-Resistant (XDR) Type IV Secretion System-Encoding Plasmid in Acinetobacter","year":2025,"lang":"en","type":"article","venue":"Pathogens","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research; University of Ottawa","keywords":"Acinetobacter baumannii; Plasmid; Microbiology; Biology; Virulence; Antibiotic resistance; Acinetobacter; Pathogen; Multiple drug resistance; Drug resistance; Human pathogen; Horizontal gene transfer; Gene; Genetics; Antibiotics; Bacteria; Genome; Pseudomonas aeruginosa","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002203365,0.00009719397,0.000180267,0.00007502594,0.00004277028,0.000005941125,0.0001778894,0.0001006856,0.000003795249],"category_scores_gemma":[0.00007943255,0.00008302307,0.00004636662,0.0002434893,0.00006040569,0.000008140149,0.0001754179,0.00005619665,5.290893e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000439987,"about_ca_system_score_gemma":0.00005608011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006161871,"about_ca_topic_score_gemma":0.000325066,"domain_scores_codex":[0.9991535,0.0001381019,0.0002733796,0.0002143546,0.00009497796,0.000125664],"domain_scores_gemma":[0.9993995,0.00001079445,0.00016635,0.0002827011,0.0001231939,0.00001749021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000202307,0.00002870113,0.2937685,0.00009794249,0.000007430055,0.000001945389,0.0001253619,0.000004624793,0.7056461,0.00008548206,0.000003359041,0.00002830633],"study_design_scores_gemma":[0.0003285336,0.00003578791,0.8367371,0.0002252578,0.00001435808,8.091887e-7,0.0002726459,0.0001089557,0.1621551,0.000004768472,0.00004811882,0.0000685806],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990134,0.00004524478,0.00009111704,0.00002702526,0.0002158657,0.0002339335,0.00009640575,0.000003906219,0.0002731531],"genre_scores_gemma":[0.9996746,0.00004961654,0.00006298842,0.00003007557,0.00002165505,0.000001829211,0.00006418391,0.000007024798,0.00008809647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5434909,"threshold_uncertainty_score":0.3385583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009907856152662627,"score_gpt":0.2255313790803097,"score_spread":0.215623522927647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}