{"id":"W4411465227","doi":"10.1002/ctm2.70369","title":"Splicing to keep splicing: A feedback system for cellular homeostasis and state transition","year":2025,"lang":"en","type":"review","venue":"Clinical and Translational Medicine","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Key Research and Development Projects of Shaanxi Province; National Natural Science Foundation of China","keywords":"RNA splicing; Alternative splicing; microRNA; Biology; Computational biology; Spliceosome; Gene isoform; Gene; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001168825,0.0006643438,0.000827488,0.0005204788,0.0007526155,0.001886819,0.0009260133,0.0009756233,0.003476464],"category_scores_gemma":[0.0009390979,0.0002975843,0.0007084112,0.0004700679,0.001988973,0.001785304,0.001264907,0.001293473,0.001384752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008836489,"about_ca_system_score_gemma":0.001081931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003839642,"about_ca_topic_score_gemma":0.0003277633,"domain_scores_codex":[0.9991334,0.0001878323,0.00008315239,0.0002925301,0.0002141815,0.00008898823],"domain_scores_gemma":[0.9994037,0.0001793864,0.000138132,0.00006414985,0.0001534654,0.00006127483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002869014,0.00004944235,0.002507132,0.004370654,0.0002212667,0.001701647,0.001487005,0.003673665,0.5463936,0.2283372,0.009370697,0.2016008],"study_design_scores_gemma":[0.00005206546,0.0007138919,0.005643891,0.0009121426,0.000337875,0.003793905,0.001083421,0.01260588,0.2894099,0.1778288,0.5073894,0.0002287826],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.1261369,0.3136566,0.4742391,0.01175107,0.009548132,0.0003172105,0.001401733,0.004009089,0.05894016],"genre_scores_gemma":[0.7335485,0.1648043,0.06999628,0.003872369,0.003097591,0.0004336548,0.00121064,0.0004887117,0.02254792],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003476464,"threshold_uncertainty_score":0.01162994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06214383765218297,"score_gpt":0.3966889949260184,"score_spread":0.3345451572738355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}