{"id":"W4411465702","doi":"10.1016/j.freeradbiomed.2025.06.032","title":"Fe2O3 nanoparticles induce ferroptosis by binding to the N-terminus of ACSL4 and suppressing its ubiquitin-mediated degradation","year":2025,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Ubiquitin; Chemistry; Ubiquitin ligase; Biochemistry; Cell biology; Arachidonic acid; Protein degradation; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479049,0.0002051774,0.0001920747,0.0001579968,0.0001720266,0.0001597105,0.0001639225,0.000306437,0.001283758],"category_scores_gemma":[0.0001162919,0.0001083424,0.0002223793,0.00009375868,0.0001927307,0.0001314698,0.000144747,0.0004071068,0.0002447851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000472765,"about_ca_system_score_gemma":0.0002359823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001178193,"about_ca_topic_score_gemma":0.001769826,"domain_scores_codex":[0.9999058,0.000013281,0.000007924442,0.00001783778,0.00002412753,0.00003111532],"domain_scores_gemma":[0.9999344,0.00001041253,0.00001595898,0.00000623605,0.0000174626,0.00001549329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001932791,0.00002574553,0.0001299889,0.00001867466,0.000005438416,0.0000222337,0.000007039646,0.00003450559,0.9987153,0.0000565587,0.00007898278,0.0007123082],"study_design_scores_gemma":[0.00001486112,0.00006526639,0.0007551939,0.000001852731,0.000006143534,0.00005632392,0.00001108216,0.000583755,0.997676,0.00003578371,0.0007913828,0.000002358944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935441,0.0006683229,0.003966578,0.0002189179,0.00006164238,0.00002726688,0.0001577344,0.00009880578,0.001256631],"genre_scores_gemma":[0.9943708,0.0001669081,0.002224645,0.00009495954,0.00000920307,0.00001582113,0.0002110808,0.00001722386,0.002889324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001283758,"threshold_uncertainty_score":0.004294634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02343935800585564,"score_gpt":0.314935905906413,"score_spread":0.2914965479005573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}