{"id":"W4411466134","doi":"10.1113/jp289040","title":"Computational modelling of cardiac fibroblast signalling reveals a key role for Ca<sup>2+</sup> in driving atrial fibrillation‐associated fibrosis","year":2025,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Heart, Lung, and Blood Institute; National Institute on Aging; National Institutes of Health","keywords":"Fibrosis; Atrial fibrillation; Angiotensin II; Extracellular matrix; Periostin; Myofibroblast; Internal medicine; Cardiac fibrosis; Fibronectin; Chemistry; Sinus rhythm; Cell biology; Endocrinology; Medicine; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001769954,0.0005711564,0.0006349007,0.0002847155,0.000354472,0.001054391,0.0006504008,0.001624245,0.003874167],"category_scores_gemma":[0.0006312103,0.0002575117,0.0006943736,0.0002899313,0.0004503089,0.0004058255,0.0005234987,0.0005242989,0.0002697596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004343062,"about_ca_system_score_gemma":0.0007643488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01320214,"about_ca_topic_score_gemma":0.007000642,"domain_scores_codex":[0.9999279,0.00001982382,0.000003367612,0.00001600249,0.00001398377,0.00001900268],"domain_scores_gemma":[0.999749,0.0001546558,0.00002643221,0.00001215795,0.00003031774,0.00002744089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00004768774,0.00002574144,0.0008096069,0.00003401699,0.00001739233,0.00006079459,0.00001340733,0.9949537,0.001576317,0.00128369,0.0002734219,0.0009041284],"study_design_scores_gemma":[0.00001008741,0.00001083257,0.0002148101,0.000002894591,0.000004019186,0.000007286091,0.000007963006,0.9990141,0.0001259205,0.0004056777,0.0001931233,0.000003228534],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8753844,0.001252809,0.07766326,0.001503069,0.0002515999,0.00008046855,0.002418492,0.0004757241,0.04097024],"genre_scores_gemma":[0.9891361,0.000311261,0.006602366,0.0001299049,0.00002662566,0.00007481771,0.0004984821,0.00004452189,0.003175942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01320214,"threshold_uncertainty_score":0.0262506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03252756219688763,"score_gpt":0.2981873237647334,"score_spread":0.2656597615678458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}