{"id":"W4411470807","doi":"10.7554/elife.105887.2","title":"Phage-displayed synthetic library and screening platform for nanobody discovery","year":2025,"lang":"en","type":"preprint","venue":"eLife","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Phage display; Single-domain antibody; Computational biology; Synthetic biology; Peptide library; Antibody; Biology; Computer science; Molecular biology; Genetics; Peptide sequence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000873091,0.0008222359,0.0007866589,0.001334224,0.0003484992,0.0007763614,0.0007378669,0.0005887428,0.002287667],"category_scores_gemma":[0.0006709942,0.0003460723,0.0005407564,0.0009636856,0.0002411886,0.0002878272,0.0007001451,0.0006488328,0.002382114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004291913,"about_ca_system_score_gemma":0.0004184401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002775521,"about_ca_topic_score_gemma":0.0004487675,"domain_scores_codex":[0.9992216,0.0001593523,0.00006869598,0.0001433954,0.0003128157,0.00009414231],"domain_scores_gemma":[0.9996896,0.00005888315,0.00004534802,0.00004956548,0.00009214858,0.00006452424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001026959,0.0001276621,0.0002042519,0.0001395794,0.00002354648,0.0001434926,0.00003062137,0.0007663796,0.989521,0.0004225865,0.0004117047,0.008106359],"study_design_scores_gemma":[0.00003083808,0.0004163569,0.0006049793,0.00001637103,0.0000409073,0.0003004276,0.000024917,0.003356632,0.9847391,0.0001508878,0.01029879,0.00001985849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.5677953,0.003313152,0.4010539,0.0004378769,0.0002091203,0.002073755,0.008569029,0.003223001,0.01332492],"genre_scores_gemma":[0.7327556,0.00293681,0.228295,0.0003841302,0.00006712488,0.001708688,0.01783757,0.0004200325,0.0155951],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002287667,"threshold_uncertainty_score":0.007652998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03811979967167577,"score_gpt":0.3332773467343473,"score_spread":0.2951575470626715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}