{"id":"W4411473071","doi":"10.1513/annalsats.202501-103oc","title":"Clinical Effectiveness of Elexacaftor/Tezacaftor/Ivacaftor in 6- to 11-Year-Olds with Cystic Fibrosis: An Observational Study","year":2025,"lang":"en","type":"article","venue":"Annals of the American Thoracic Society","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; University of Alabama at Birmingham; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Ivacaftor; Medicine; Cystic fibrosis; Sputum; Internal medicine; Sputum culture; Anthropometry; Gastroenterology; Cystic fibrosis transmembrane conductance regulator; Pathology; Tuberculosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00211941,0.0003456878,0.0007633326,0.0005352948,0.0005645165,0.0007574654,0.0005083292,0.0008199067,0.0009739459],"category_scores_gemma":[0.0047806,0.0002819679,0.00115084,0.0008224166,0.0004276955,0.0008817729,0.0005037481,0.001047852,0.0002513195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005468656,"about_ca_system_score_gemma":0.0005033744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004158271,"about_ca_topic_score_gemma":0.004259436,"domain_scores_codex":[0.9981219,0.0007361496,0.0002608947,0.0003755,0.000321819,0.000183607],"domain_scores_gemma":[0.994724,0.001114392,0.002736378,0.000250603,0.000388521,0.000786112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001301456,0.0002898743,0.9969867,0.0000318034,0.0002110031,0.00005249202,0.00005280356,0.00002345004,0.000115206,0.000007850713,0.00008916923,0.0008383251],"study_design_scores_gemma":[0.0002185587,0.00269857,0.9958177,0.00003056301,0.0002695938,0.0002394517,0.0002157431,0.0001968572,0.00007803599,0.000009698912,0.0002177238,0.00000761484],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989003,0.000576126,0.00002362879,0.00003028386,0.000005452127,0.00001751516,0.0003067594,0.000001072804,0.0001387031],"genre_scores_gemma":[0.9990979,0.0002271975,0.0000521129,0.00005675546,0.00001909976,0.0000196955,0.0004761545,8.976624e-7,0.00005025935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004158271,"threshold_uncertainty_score":0.01120865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1597380297234669,"score_gpt":0.5123702318447263,"score_spread":0.3526322021212593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}