{"id":"W4411489485","doi":"10.1039/d5nj00175g","title":"Synthesis and biological studies on ovarian cancer cells of new heterocyclic molecules inspired by MIM1, an inhibitor of the anti-apoptotic protein Mcl-1","year":2025,"lang":"en","type":"article","venue":"New Journal of Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Social Fund; European Regional Development Fund; Région Normandie; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Université Libanaise; Conseil National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; Agence Universitaire de la Francophonie; European Commission","keywords":"Chemistry; Apoptosis; Bioorganic chemistry; Small molecule; Molecule; Cancer; Cancer research; Cancer cell; Combinatorial chemistry; Biochemistry; Organic chemistry; Enzyme; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007497073,0.0001528839,0.0001311721,0.000210606,0.0001101768,0.00008392262,0.0001348186,0.0001511622,0.001157372],"category_scores_gemma":[0.00006467468,0.00005607133,0.000182559,0.000121728,0.00009048086,0.0001273535,0.00007638225,0.0001953647,0.0001951554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008747663,"about_ca_system_score_gemma":0.00008965822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002737932,"about_ca_topic_score_gemma":0.0005009152,"domain_scores_codex":[0.9999748,0.00000426785,0.00000131143,0.000005672675,0.000005851791,0.000008011466],"domain_scores_gemma":[0.9999706,0.000006966841,0.000006930434,0.000003731348,0.000004556086,0.000007323363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001626124,0.00007931691,0.0001273955,0.000123346,0.000007485803,0.00007923919,0.00003404735,0.000577678,0.994235,0.0002777047,0.00007628866,0.004219858],"study_design_scores_gemma":[0.00005445026,0.00192938,0.002626398,0.000007748981,0.00002213226,0.0001303648,0.00002255202,0.0008668453,0.9904303,0.00007211747,0.00382969,0.000008056852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914474,0.003288948,0.001520722,0.0000755578,0.00002533105,0.00005733412,0.0003784989,0.00002948227,0.003176699],"genre_scores_gemma":[0.9932981,0.002144369,0.001963208,0.00004704692,0.00001382889,0.0000309997,0.0003707701,0.00001005734,0.002121553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001157372,"threshold_uncertainty_score":0.003871799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02831934538530688,"score_gpt":0.2724730504668783,"score_spread":0.2441537050815714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}