{"id":"W4411509767","doi":"10.1101/2025.06.20.660705","title":"RNF13 is a novel interactor of iduronate 2-sulfatase that modifies its glycosylation and maturation","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"Centre d’Excellence en Recherche sur les Maladies Orphelines – Fondation Courtois","keywords":"Ubiquitin ligase; Glycosylation; Immunoprecipitation; Mucopolysaccharidosis type II; Biology; Ubiquitin; Cell biology; Hunter syndrome; Proteasome; HEK 293 cells; DNA ligase; Intracellular; Biochemistry; Computational biology; Gene; Enzyme replacement therapy; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001665822,0.0005796283,0.0003148351,0.0002143273,0.0002359722,0.0002089305,0.0002928506,0.0004887871,0.001145268],"category_scores_gemma":[0.0001569066,0.0001209615,0.0004123398,0.0001382066,0.0001102943,0.000103556,0.0001624281,0.0002167579,0.0006513803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004508731,"about_ca_system_score_gemma":0.0001319214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077483,"about_ca_topic_score_gemma":0.001003962,"domain_scores_codex":[0.9998523,0.00002734158,0.0000156494,0.00003998258,0.00003352741,0.00003130067],"domain_scores_gemma":[0.9999092,0.000009469742,0.00003490333,0.000007091643,0.00001216627,0.00002723921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002803318,0.00004445034,0.004269444,0.00004519932,0.00004280965,0.001891202,0.00001206305,0.0001821651,0.9890582,0.0001395892,0.0003619542,0.003672565],"study_design_scores_gemma":[0.00005324422,0.0002712873,0.04345408,0.00001726225,0.00009961097,0.01459024,0.00003839198,0.008607134,0.9202517,0.0001153339,0.01247286,0.00002884471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914857,0.002132854,0.00491572,0.0001124298,0.000068612,0.00001819218,0.0003052624,0.0001293312,0.0008319089],"genre_scores_gemma":[0.9925615,0.0005350832,0.002595593,0.0000956861,0.0000188434,0.00001730451,0.0008914364,0.00002102875,0.003263453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145268,"threshold_uncertainty_score":0.003831327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03321161082706824,"score_gpt":0.2784046891828736,"score_spread":0.2451930783558054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}