{"id":"W4411536016","doi":"10.3892/ol.2025.15151","title":"Evidence of a functional Smad2/3 signaling axis and TGFβ‑mediated autocrine transcriptional regulation of <i>in vitro</i> vasculogenic mimicry in mesenchymal stem/stromal cells","year":2025,"lang":"en","type":"article","venue":"Oncology Letters","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Vasculogenic mimicry; Autocrine signalling; Mesenchymal stem cell; Cell biology; Oncogene; Biology; In vitro; Stromal cell; Cell cycle; Molecular medicine; Cancer research; Transforming growth factor; Cell; Cancer; Cell culture; Genetics; Metastasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001774468,0.0004570819,0.0001725906,0.0002651534,0.0001297788,0.0003224654,0.0001273764,0.0001658446,0.001800434],"category_scores_gemma":[0.00009932695,0.0001718051,0.0004237448,0.000127879,0.0002715207,0.0001445887,0.0001747697,0.0005044569,0.0004633795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000201031,"about_ca_system_score_gemma":0.0003122539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005132667,"about_ca_topic_score_gemma":0.0008098396,"domain_scores_codex":[0.9998265,0.00002736652,0.00001678299,0.00002730137,0.00006046305,0.0000416139],"domain_scores_gemma":[0.9998504,0.00002233812,0.00004737727,0.00001904246,0.00002320295,0.00003764494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005092187,0.0000152222,0.0001586975,0.00003659408,0.000003760902,0.00005351739,0.00001346359,0.00002247525,0.9989789,0.00009973851,0.00002303432,0.0005436245],"study_design_scores_gemma":[0.00001763008,0.0002029429,0.009717229,0.000009189853,0.000018074,0.0004872853,0.00005545226,0.0006068628,0.9856516,0.00007875899,0.003150507,0.000004363354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770464,0.003559999,0.0114103,0.0002320577,0.00009630385,0.00006100332,0.001374705,0.0001668777,0.006052255],"genre_scores_gemma":[0.9893599,0.001691126,0.004104779,0.0001318383,0.00003000469,0.00007480824,0.001697347,0.00002922919,0.002881019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001800434,"threshold_uncertainty_score":0.006023109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04182610641340076,"score_gpt":0.2999406775401545,"score_spread":0.2581145711267537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}