{"id":"W4411538460","doi":"10.1128/aac.01700-24","title":"Synthetic host defense peptide inhibits SARS-CoV-2 replication <i>in vitro</i>","year":2025,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of British Columbia; Western University","funders":"Canadian Institutes of Health Research; Ministry of Business, Innovation and Employment; Ministry of Health, New Zealand","keywords":"In vitro; Replication (statistics); Host (biology); Virology; Biology; Viral replication; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Peptide; Betacoronavirus; Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Virus; Genetics; Medicine; Biochemistry; Infectious disease (medical specialty); Outbreak","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009983307,0.0002663217,0.0001833372,0.0001047881,0.00005964325,0.0001274673,0.0001208198,0.0001397109,0.001009213],"category_scores_gemma":[0.0000887588,0.00005916311,0.0001732469,0.00007963162,0.00008587314,0.00007764487,0.00007614589,0.000256212,0.0002765415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008816493,"about_ca_system_score_gemma":0.00009230373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002854284,"about_ca_topic_score_gemma":0.0002717882,"domain_scores_codex":[0.9999336,0.00001509273,0.000009119404,0.000009713538,0.00001809944,0.00001434742],"domain_scores_gemma":[0.9999421,0.00001624199,0.00001319598,0.000007271648,0.000008637001,0.00001260431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000110049,0.00003812381,0.0001061414,0.00002428616,0.00000232671,0.00002111651,0.000003475772,0.00009363287,0.9986798,0.00001724378,0.00002483024,0.0008790246],"study_design_scores_gemma":[0.00001589382,0.001406418,0.001338282,0.000003711804,0.000005808928,0.000158412,0.0000105479,0.0008594751,0.9955047,0.0000136655,0.0006802773,0.00000288929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966353,0.0008108619,0.0009049632,0.0000255875,0.00001506028,0.00002056378,0.000291787,0.00003880847,0.001257167],"genre_scores_gemma":[0.9962424,0.0004720071,0.001543062,0.00004578339,0.000007139257,0.00001601696,0.0007273939,0.000008364974,0.0009378509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009213,"threshold_uncertainty_score":0.003376186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02453072725603014,"score_gpt":0.3243731422084472,"score_spread":0.299842414952417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}