{"id":"W4411539488","doi":"10.1161/atv.45.suppl_1.or112","title":"Abstract Or112: Indoxyl Sulfate Suppresses GAS6 and Impairs Anti-Atherogenic Macrophage Function: A Novel Mechanism Driving Accelerated Atherosclerosis in Chronic Kidney Disease","year":2025,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Biomarkers in Disease Mechanisms","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Efferocytosis; Medicine; Kidney disease; Macrophage; In vivo; GAS6; Kidney; Endocrinology; Pharmacology; Internal medicine; Foam cell; Apoptosis; Cancer research; Biology; Cholesterol; Receptor; In vitro; Lipoprotein; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005444161,0.0006240609,0.0008682224,0.0003811941,0.0004980109,0.000129471,0.0003810245,0.0006618113,0.0007162075],"category_scores_gemma":[0.0001024684,0.0005787849,0.0002714259,0.0004833928,0.0005727135,0.0002386836,0.0004922135,0.0004239742,0.00004214005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001515007,"about_ca_system_score_gemma":0.0002253082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001741388,"about_ca_topic_score_gemma":0.000107839,"domain_scores_codex":[0.9967685,0.0003352691,0.0006915947,0.001222545,0.00006718369,0.000914861],"domain_scores_gemma":[0.9986572,0.0001487146,0.0002045097,0.0006971716,0.00008257604,0.0002098078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003370388,0.000300551,0.1043783,0.000134491,0.0008239171,3.080467e-7,0.0001018542,0.000001744217,0.8916851,0.001883607,0.0001739056,0.0004824585],"study_design_scores_gemma":[0.004581726,0.0002349418,0.9705245,0.0004629414,0.0003580351,0.000001375144,0.0001450478,0.00007101291,0.02142138,0.0005681666,0.001083246,0.0005476597],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994608,0.00189389,0.001049886,0.0004440329,0.0008228788,0.0007288039,0.0002452625,0.0001651108,0.00004207759],"genre_scores_gemma":[0.9929931,0.005590816,0.0001075777,0.0007318407,0.00003620543,0.0002161017,0.0002485348,0.00005775866,0.00001804832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8702638,"threshold_uncertainty_score":0.9996663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02107603232782191,"score_gpt":0.2592803923451861,"score_spread":0.2382043600173642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}