{"id":"W4411539488","doi":"10.1161/atv.45.suppl_1.or112","title":"Abstract Or112: Indoxyl Sulfate Suppresses GAS6 and Impairs Anti-Atherogenic Macrophage Function: A Novel Mechanism Driving Accelerated Atherosclerosis in Chronic Kidney Disease","year":2025,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Biomarkers in Disease Mechanisms","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Efferocytosis; Medicine; Kidney disease; Macrophage; In vivo; GAS6; Kidney; Endocrinology; Pharmacology; Internal medicine; Foam cell; Apoptosis; Cancer research; Biology; Cholesterol; Receptor; In vitro; Lipoprotein; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004541594,0.0004746655,0.0008776125,0.0004224148,0.000159765,0.0006427296,0.0003205194,0.000307047,0.002258314],"category_scores_gemma":[0.0002933474,0.0001499556,0.001092877,0.0006178663,0.0002463249,0.0002914095,0.000301721,0.0005805622,0.0003639436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002751797,"about_ca_system_score_gemma":0.0005058634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007704892,"about_ca_topic_score_gemma":0.001206306,"domain_scores_codex":[0.9996617,0.00007807365,0.00002599227,0.00009204431,0.00009709512,0.00004510694],"domain_scores_gemma":[0.9997662,0.00004145802,0.0001050672,0.00002592888,0.00002814531,0.00003318341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008665407,0.0002809765,0.03733124,0.002689589,0.002928915,0.0003940743,0.00007368559,0.001309914,0.900368,0.0006594579,0.002554984,0.04274383],"study_design_scores_gemma":[0.0008663589,0.005239316,0.5894119,0.0003847787,0.006912505,0.001977785,0.0003900453,0.009427935,0.3524591,0.002613564,0.0302151,0.0001017114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9607224,0.0246175,0.005264896,0.000836609,0.0001334655,0.00006272368,0.006602947,0.0002802766,0.001479248],"genre_scores_gemma":[0.9827033,0.007025608,0.002343993,0.000501856,0.00009072956,0.00006384493,0.005450771,0.00004555443,0.001774413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002258314,"threshold_uncertainty_score":0.00755477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02107603232782191,"score_gpt":0.2592803923451861,"score_spread":0.2382043600173642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}