{"id":"W4411540718","doi":"10.7554/elife.106402.1","title":"HIV-specific CD8+ T-cell responses soon after treatment initiation during acute HIV infection are associated with viral reservoir decline","year":2025,"lang":"en","type":"preprint","venue":"eLife","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"CD8; Immune system; Immunology; Human immunodeficiency virus (HIV); Cytotoxic T cell; Antiretroviral therapy; Viral load; Virology; CD4-CD8 Ratio; T cell; Biology; Cell; Medicine; Lymphocyte subsets; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002324653,0.0001710017,0.0002406752,0.0002321709,0.0001455459,0.0003689475,0.0001319963,0.0002778277,0.004376632],"category_scores_gemma":[0.0006330208,0.00009100758,0.00009710217,0.0001202652,0.0001667808,0.0001828597,0.0001966884,0.0005237677,0.0009002442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001780907,"about_ca_system_score_gemma":0.0001135997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000307267,"about_ca_topic_score_gemma":0.0002425714,"domain_scores_codex":[0.9998926,0.00001901936,0.000006475957,0.00001984438,0.00002336478,0.00003878766],"domain_scores_gemma":[0.9996747,0.00008335985,0.00008976471,0.00002650448,0.00004194027,0.00008375446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002275106,0.0002748037,0.07398906,0.0001831876,0.00002419334,0.0006327007,0.0002741639,0.0004766585,0.8836117,0.0002227177,0.001151585,0.03688414],"study_design_scores_gemma":[0.00007859858,0.001627157,0.6528337,0.000057672,0.00003397162,0.001885963,0.0005847558,0.002330745,0.3325989,0.0008097698,0.007138062,0.00002066451],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961166,0.0008217718,0.0008081208,0.0001114258,0.00002787321,0.00001681801,0.0004350464,0.00006296469,0.001599234],"genre_scores_gemma":[0.9961086,0.0001689094,0.0004689181,0.00004487201,0.00001623366,0.00002246867,0.0003744019,0.00001268525,0.002782938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004376632,"threshold_uncertainty_score":0.01464123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02267659705656637,"score_gpt":0.280276825540451,"score_spread":0.2576002284838846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}