{"id":"W4411540738","doi":"10.7554/elife.106402","title":"HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation is associated with the subsequent reduction in the viral reservoir","year":2025,"lang":"en","type":"preprint","venue":"eLife","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Radboud Universitair Medisch Centrum; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; amfAR, The Foundation for AIDS Research; Radboud Universiteit; Erasmus Universitair Medisch Centrum Rotterdam; Aids Fonds; Gilead Sciences","keywords":"Human immunodeficiency virus (HIV); Viral infection; Virology; Immunology; Medicine; CD8; Cytotoxic T cell; Immune system; Virus; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002340146,0.0002351914,0.00030739,0.0002428861,0.0001623595,0.000361294,0.0001594889,0.0003331323,0.006207525],"category_scores_gemma":[0.0004714224,0.0001066974,0.0001139178,0.000153713,0.0001881173,0.0001803216,0.000253349,0.0006724896,0.001706297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002011702,"about_ca_system_score_gemma":0.0001648682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003264333,"about_ca_topic_score_gemma":0.0003887502,"domain_scores_codex":[0.9998707,0.00001823976,0.000005784387,0.00003265367,0.00003281053,0.00003975871],"domain_scores_gemma":[0.9998364,0.00003732792,0.00003961644,0.00001683011,0.00002548086,0.00004426553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001920294,0.0003100391,0.01899907,0.0002315195,0.00002651608,0.0002908936,0.0002209649,0.0005242571,0.916613,0.0003465964,0.001761685,0.05875512],"study_design_scores_gemma":[0.0001442538,0.002328043,0.3101982,0.00009464534,0.00004560707,0.001269327,0.000620554,0.002108493,0.6575422,0.001290137,0.02432843,0.00003014124],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895588,0.002092052,0.00166631,0.0003042636,0.0000821389,0.00003134139,0.001042413,0.0001683745,0.005054273],"genre_scores_gemma":[0.9829028,0.0007814923,0.001566766,0.00008759417,0.00004571423,0.00007249793,0.000971327,0.00003044275,0.01354134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006207525,"threshold_uncertainty_score":0.02076626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02790188859159299,"score_gpt":0.2747594017227579,"score_spread":0.2468575131311649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}