{"id":"W4411550193","doi":"10.1007/978-1-0716-4654-0_17","title":"Cleavage Under Targets &amp; Release Using Nuclease (CUT&amp;RUN) Protocols for the Study of Genetic and Epigenetic Regulation in Cancer","year":2025,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"","keywords":"Nuclease; Epigenetics; Cleavage (geology); Cancer; Cell biology; Chemistry; Biology; Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00201905,0.001118137,0.0008786492,0.001298386,0.00131648,0.0010292,0.001029753,0.0007453567,0.006699854],"category_scores_gemma":[0.001451638,0.001173442,0.0008368643,0.001317117,0.0007679599,0.0008001907,0.0007018356,0.003003481,0.004106937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005948747,"about_ca_system_score_gemma":0.001712603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001471775,"about_ca_topic_score_gemma":0.004956374,"domain_scores_codex":[0.9986448,0.0003609789,0.0001496218,0.0002683821,0.0004224611,0.0001537042],"domain_scores_gemma":[0.9990108,0.0002356611,0.0001097265,0.0003511547,0.0002118113,0.000080863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002049286,0.00005245324,0.0002647132,0.0003562912,0.00003945884,0.0001503912,0.0002163594,0.000239536,0.9659304,0.002548034,0.003396223,0.02660118],"study_design_scores_gemma":[0.00003356789,0.0001234661,0.001987006,0.00005067869,0.00005858638,0.0007041927,0.00003896647,0.001124219,0.9485001,0.0008449382,0.0464991,0.00003513535],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.07452777,0.005514596,0.8993194,0.000746313,0.0004949429,0.001343294,0.004043422,0.003453196,0.01055707],"genre_scores_gemma":[0.1402371,0.009412462,0.780908,0.0005464418,0.0001351396,0.003413203,0.02052435,0.00202417,0.04279913],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.006699854,"threshold_uncertainty_score":0.02241325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03958798421280968,"score_gpt":0.4214923775709158,"score_spread":0.3819043933581062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}