{"id":"W4411550209","doi":"10.1007/978-1-0716-4654-0_13","title":"Chimeric Antigen Receptor T Cell Production for Brain Cancers","year":2025,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Chimeric antigen receptor; Antigen; Cancer research; Neuroscience; Biology; Computational biology; Immunology; Immunotherapy; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037964,0.0005785244,0.0003847118,0.0005041067,0.0002838352,0.0006387554,0.0005803262,0.000643275,0.00353796],"category_scores_gemma":[0.0003092433,0.0002781378,0.0004151323,0.00026824,0.0002367065,0.000339787,0.0003496932,0.001758437,0.001399527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003954464,"about_ca_system_score_gemma":0.0003887613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009800278,"about_ca_topic_score_gemma":0.0006358296,"domain_scores_codex":[0.999805,0.00003466164,0.00001442647,0.0000423489,0.00004225272,0.0000612843],"domain_scores_gemma":[0.9998455,0.00004768446,0.00002290654,0.00002663386,0.00002814803,0.00002911753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002966632,0.00009390584,0.00007304591,0.0001129396,0.00001743736,0.0001525141,0.00005746111,0.0003999058,0.9916979,0.001252293,0.0006771028,0.005168986],"study_design_scores_gemma":[0.0000742424,0.0003032739,0.0002027329,0.00001232422,0.00004597146,0.0003314084,0.00001989946,0.001424621,0.9864511,0.0001670336,0.01096175,0.000005668977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8405827,0.01004777,0.1254577,0.001161919,0.0007042181,0.0009666441,0.00385241,0.001275762,0.01595084],"genre_scores_gemma":[0.9570377,0.003627387,0.02692454,0.0001354639,0.00008992491,0.0003470614,0.00215634,0.0001754377,0.009506097],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.00353796,"threshold_uncertainty_score":0.01183563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03439582199666977,"score_gpt":0.4687643660926454,"score_spread":0.4343685440959756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}