{"id":"W4411554595","doi":"10.58931/cibdt.2025.3142","title":"Is There Still a Role for Proactive Therapeutic Drug Monitoring (TDM) in Inflammatory Bowel Disease (IBD): A Review of the Literature","year":2025,"lang":"en","type":"review","venue":"Canadian IBD Today","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"McGill University","keywords":"Inflammatory bowel disease; Medicine; Therapeutic drug monitoring; Drug; Intensive care medicine; Disease; Inflammatory Bowel Diseases; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001319901,0.000757446,0.002474649,0.002602816,0.00030328,0.001433861,0.001210858,0.001746762,0.003912335],"category_scores_gemma":[0.00315312,0.0002727807,0.001047293,0.002766075,0.0006887469,0.002268638,0.0008194345,0.002190861,0.001305709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009680493,"about_ca_system_score_gemma":0.002070765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00218591,"about_ca_topic_score_gemma":0.003939692,"domain_scores_codex":[0.9994699,0.0001341236,0.0001122485,0.00008612287,0.0001597026,0.0000379008],"domain_scores_gemma":[0.9976901,0.001425037,0.0003197724,0.00003941898,0.0003881331,0.0001375656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000107887,0.00004211458,0.0002533897,0.03615552,0.0001758579,0.0001467692,0.00006002254,0.0001887941,0.0002897148,0.001493968,0.03305071,0.9280353],"study_design_scores_gemma":[0.00005722808,0.0001482073,0.001707518,0.03063488,0.0006709851,0.001881961,0.0001665314,0.0001346316,0.0001557182,0.002224048,0.9621834,0.00003496648],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003011074,0.9991658,0.00003339646,0.0004422434,0.0001303457,0.00000168248,0.000007401861,0.000003150868,0.0001859741],"genre_scores_gemma":[0.0003560383,0.9988472,0.0001052456,0.0003815714,0.0002004628,0.000003399276,0.00001280696,0.000001032776,0.00009220477],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003912335,"threshold_uncertainty_score":0.01308805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01018281083329612,"score_gpt":0.2688398041164764,"score_spread":0.2586569932831803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}