{"id":"W4411555666","doi":"10.1016/j.cell.2025.05.042","title":"GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity","year":2025,"lang":"en","type":"article","venue":"Cell","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science for Life Laboratory; Vetenskapsrådet; Novo Nordisk; Insamlingsstiftelsen Diabetes Wellness Network Sverige; Novo Nordisk Fonden; Svenska Sällskapet för Medicinsk Forskning; National Science Council; Knut och Alice Wallenbergs Stiftelse; Robert Bosch Stiftung; Deutsche Forschungsgemeinschaft; Cancerfonden; Augusta University; European Foundation for the Study of Diabetes; Uppsala Multidisciplinary Center for Advanced Computational Science; European Federation of Pharmaceutical Industries and Associations; Karolinska Institutet; McGill University","keywords":"Biology; Type 2 diabetes; Obesity; Endocrinology; Internal medicine; Adrenergic; Diabetes mellitus; Pharmacology; Receptor; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003877787,0.00005335872,0.00006934624,0.000008140026,0.00005006733,0.000006853742,0.00004413352,0.00004291491,0.0000118643],"category_scores_gemma":[0.00000638859,0.00003510195,0.00004309132,0.0000247879,0.00002153655,4.179983e-7,0.00001197081,0.000008255633,3.5406e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003664861,"about_ca_system_score_gemma":0.00002019416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000057403,"about_ca_topic_score_gemma":0.000003795413,"domain_scores_codex":[0.9997371,0.000009416806,0.00005922958,0.000102929,0.00001890133,0.00007242282],"domain_scores_gemma":[0.9997997,0.00002214263,0.00002184532,0.0001136532,0.00002887412,0.00001382423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002226314,0.00005822475,0.0007753837,0.0000218248,0.00003075528,7.119016e-8,0.00002453663,0.00002920755,0.9961152,0.0001159575,0.0003007203,0.002505858],"study_design_scores_gemma":[0.0003223444,0.0003422706,0.0003454855,0.000004029131,0.00003001268,4.807355e-8,0.00002331084,0.0002182087,0.9645787,0.0001203044,0.03397895,0.00003626932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922155,0.006505779,0.0006248524,0.00002470506,0.0001402677,0.0001281328,0.000007070309,0.000002138655,0.0003515176],"genre_scores_gemma":[0.9964889,0.0009383468,0.000263962,0.00004786989,0.00004259198,0.00001329631,0.00002683547,0.00000395867,0.002174204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03367823,"threshold_uncertainty_score":0.1431416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008627477684094722,"score_gpt":0.2324168833962265,"score_spread":0.2237894057121317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}