{"id":"W4411555666","doi":"10.1016/j.cell.2025.05.042","title":"GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity","year":2025,"lang":"en","type":"article","venue":"Cell","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science for Life Laboratory; Vetenskapsrådet; Novo Nordisk; Insamlingsstiftelsen Diabetes Wellness Network Sverige; Novo Nordisk Fonden; Svenska Sällskapet för Medicinsk Forskning; National Science Council; Knut och Alice Wallenbergs Stiftelse; Robert Bosch Stiftung; Deutsche Forschungsgemeinschaft; Cancerfonden; Augusta University; European Foundation for the Study of Diabetes; Uppsala Multidisciplinary Center for Advanced Computational Science; European Federation of Pharmaceutical Industries and Associations; Karolinska Institutet; McGill University","keywords":"Biology; Type 2 diabetes; Obesity; Endocrinology; Internal medicine; Adrenergic; Diabetes mellitus; Pharmacology; Receptor; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001345488,0.0002723934,0.0003298428,0.0002154867,0.0001132791,0.0002757007,0.0002241356,0.0002881036,0.001824443],"category_scores_gemma":[0.00008190449,0.00009882631,0.0002546364,0.0001914324,0.0001563154,0.0001678871,0.0002500947,0.0008296769,0.0004756595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001737581,"about_ca_system_score_gemma":0.0001434538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002299231,"about_ca_topic_score_gemma":0.0008899677,"domain_scores_codex":[0.9999388,0.000013787,0.000003447267,0.00001096888,0.00001810633,0.00001483349],"domain_scores_gemma":[0.9999794,0.00000271192,0.000007263173,0.000001631499,0.000002990145,0.000006062841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001737371,0.0007662287,0.0009936988,0.001415489,0.0001774477,0.0009513053,0.00008161882,0.003534559,0.7194461,0.005584095,0.005611225,0.2597008],"study_design_scores_gemma":[0.003263872,0.01532031,0.0134531,0.0007805419,0.0007829977,0.009423958,0.0002127555,0.01404087,0.6124514,0.00521023,0.3248708,0.0001890407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6369494,0.3008426,0.02453644,0.002937829,0.001030024,0.0004122628,0.001363764,0.0006981487,0.03122951],"genre_scores_gemma":[0.889992,0.0882645,0.01050111,0.001754982,0.0001423755,0.0001595621,0.0007049697,0.00003966076,0.008440888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001824443,"threshold_uncertainty_score":0.006103337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008627477684094722,"score_gpt":0.2324168833962265,"score_spread":0.2237894057121317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}