{"id":"W4411555888","doi":"10.21203/rs.3.rs-6771517/v1","title":"P2RX7 regulates tauopathy progression via tau and mitochondria loading in extracellular vesicles","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Cure Alzheimer's Fund; National Institutes of Health; Alzheimer's Association; Mayo Clinic","keywords":"Tauopathy; Microglia; Neurodegeneration; Cell biology; Biology; Neuroinflammation; Neuroscience; Cognitive decline; Inflammation; Immunology; Disease; Pathology; Medicine; Dementia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003091434,0.000429248,0.0004499879,0.000379571,0.0005661567,0.001501222,0.0003625196,0.001143543,0.003450466],"category_scores_gemma":[0.0003520993,0.0002346852,0.0005369403,0.0002577868,0.0005242932,0.001204822,0.0006553736,0.00124228,0.001692479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004709496,"about_ca_system_score_gemma":0.0003151823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003992302,"about_ca_topic_score_gemma":0.000313363,"domain_scores_codex":[0.9997348,0.00004164574,0.00001553936,0.00006182573,0.00007810058,0.00006809046],"domain_scores_gemma":[0.9998431,0.00002151613,0.00003677192,0.00001952337,0.00003880672,0.0000401263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009202614,0.00006781077,0.001199018,0.0002549293,0.00005696304,0.0008988922,0.0001963849,0.0003856137,0.9830494,0.006055516,0.001411113,0.005504061],"study_design_scores_gemma":[0.0001082746,0.0002248857,0.009036466,0.00008475149,0.0000786548,0.001379008,0.0003930056,0.006051538,0.9664795,0.005351475,0.01078333,0.00002904766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704061,0.008779855,0.01046826,0.001602562,0.0004408751,0.00004465495,0.0008720931,0.0003533553,0.00703233],"genre_scores_gemma":[0.9839872,0.002794408,0.002008688,0.0001650507,0.00009380409,0.00004221055,0.0009307566,0.0001582811,0.009819533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003450466,"threshold_uncertainty_score":0.01154292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06889627630118866,"score_gpt":0.3792664547079225,"score_spread":0.3103701784067339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}