{"id":"W4411555965","doi":"10.1016/j.immuni.2025.05.023","title":"The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway","year":2025,"lang":"en","type":"article","venue":"Immunity","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Freedom Together Foundation; National Institute on Aging; National Cancer Institute; Rainwater Charitable Foundation; National Institutes of Health; Cure Alzheimer's Fund; JPB Foundation; Howard Hughes Medical Institute","keywords":"Biology; Sting; Mutation; Gene; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002104099,0.0006140042,0.0003028859,0.0002822902,0.0001953313,0.000260527,0.0002739611,0.0005622491,0.00275178],"category_scores_gemma":[0.0002444185,0.0001718071,0.0006825631,0.000129864,0.0005830275,0.0001498241,0.000294614,0.0008471597,0.0005271751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000270898,"about_ca_system_score_gemma":0.0003212521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007950686,"about_ca_topic_score_gemma":0.0009863015,"domain_scores_codex":[0.9998248,0.00003881922,0.00002480273,0.00003241049,0.00003769233,0.00004150025],"domain_scores_gemma":[0.9997382,0.00004753415,0.00009087192,0.00003665141,0.00001446188,0.00007245141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006972479,0.00007003881,0.0007275422,0.00001562746,0.00002621753,0.0006161765,0.0000182584,0.0001218206,0.9960555,0.0002818037,0.00007093845,0.001298846],"study_design_scores_gemma":[0.0002818902,0.001505614,0.02507116,0.00002721977,0.0001177125,0.005911662,0.000106922,0.003149753,0.9585126,0.000742152,0.004522908,0.0000504582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967129,0.0001607189,0.001478216,0.0002160034,0.00008084468,0.00001923431,0.0002717021,0.0000865457,0.0009738547],"genre_scores_gemma":[0.9978614,0.00007978323,0.0006528432,0.00008013453,0.00001609298,0.00001030721,0.0001390407,0.00003207701,0.001128279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00275178,"threshold_uncertainty_score":0.00920558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009281133740260046,"score_gpt":0.2458228532400158,"score_spread":0.2365417194997557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}