{"id":"W4411568112","doi":"10.1007/s00115-025-01839-1","title":"Genetisch informierte Therapie in der Psychiatrie: neue Dynamik durch APOE und Antikörpertherapie der Alzheimer-Krankheit","year":2025,"lang":"de","type":"review","venue":"Der Nervenarzt","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Shores Centre for Mental Health Sciences","funders":"","keywords":"Philosophy; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.0009536726,0.002562905,0.003543269,0.001794537,0.0007796439,0.0007865165,0.003414751,0.00182426,0.001646747],"category_scores_gemma":[0.0003733987,0.002288115,0.002096645,0.005115944,0.0007787661,0.0007288364,0.0006971577,0.002721802,0.00192515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002273054,"about_ca_system_score_gemma":0.002265118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004510527,"about_ca_topic_score_gemma":0.001039539,"domain_scores_codex":[0.9879706,0.001542259,0.003132649,0.003173449,0.001486222,0.002694828],"domain_scores_gemma":[0.9940129,0.001291451,0.001153016,0.002739487,0.0002033288,0.0005998433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000258256,0.001708613,0.001003114,0.01045358,0.003851398,0.0004808476,0.001028182,0.0002388985,0.0001460726,0.001588652,0.01381169,0.9654307],"study_design_scores_gemma":[0.004124817,0.0003444343,0.001596139,0.006349828,0.002573282,0.0001060129,0.0000751075,0.0006477259,0.0001670903,0.0007132915,0.9804575,0.002844743],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001505941,0.9827741,0.0003006634,0.002616997,0.004238612,0.00404517,0.0003478208,0.0002793876,0.003891331],"genre_scores_gemma":[0.007240689,0.9783137,0.0004479979,0.007897872,0.0006697526,0.0005675096,0.0003793551,0.0004277549,0.004055298],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9666458,"threshold_uncertainty_score":0.999579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04100453093919485,"score_gpt":0.3462207656796137,"score_spread":0.3052162347404188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}