{"id":"W4411568546","doi":"10.1038/s41565-025-01958-5","title":"Tailoring the adjuvanticity of lipid nanoparticles by PEG lipid ratio and phospholipid modifications","year":2025,"lang":"en","type":"article","venue":"Nature Nanotechnology","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; U.S. Department of Health and Human Services","keywords":"Phospholipid; PEG ratio; Nanoparticle; Chemistry; Nanotechnology; Chemical engineering; Materials science; Biochemistry; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002505489,0.00034106,0.0001517813,0.0001494097,0.00008686078,0.0003148705,0.0001606804,0.0002867816,0.0008768715],"category_scores_gemma":[0.000497436,0.0001600372,0.0001426507,0.0001487868,0.0001767515,0.000464957,0.000259596,0.0004310285,0.0002997606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001967096,"about_ca_system_score_gemma":0.0002140473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002235365,"about_ca_topic_score_gemma":0.0003833495,"domain_scores_codex":[0.9998878,0.00001944263,0.0000147518,0.00002558791,0.00002483776,0.00002757007],"domain_scores_gemma":[0.999849,0.00004635259,0.0000475066,0.00001166315,0.0000263332,0.00001908689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001065394,0.00001835596,0.00007410825,0.00002256205,0.00000271529,0.00001532652,0.00001249199,0.000117194,0.9985014,0.0001062233,0.00001313524,0.001009887],"study_design_scores_gemma":[0.00001088548,0.00009421525,0.0001850527,0.000002922994,0.000005856084,0.00001373869,0.000005388343,0.000610726,0.9987044,0.00002473001,0.0003394998,0.000002635306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940515,0.0004598656,0.004204196,0.00008275621,0.00002293448,0.00004208002,0.0000743304,0.00004485833,0.001017368],"genre_scores_gemma":[0.9964043,0.0004306866,0.002230958,0.00005110913,0.000007735292,0.00002992652,0.00004968192,0.00001623125,0.0007794399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008768715,"threshold_uncertainty_score":0.002933443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005112118198178578,"score_gpt":0.2455211664719526,"score_spread":0.240409048273774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}