{"id":"W4411569222","doi":"10.1002/pmic.13980","title":"Covalent Inhibition of the Peptidyl‐Prolyl Isomerase Pin1 by Sulfopin Results in a Broad Impact on the Phosphoproteome of Human Osteosarcoma U2‐OS Cells","year":2025,"lang":"en","type":"article","venue":"PROTEOMICS","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Foundation for Innovation; Ontario Institute for Cancer Research","keywords":"PIN1; Osteosarcoma; Isomerase; Chemistry; Biochemistry; Covalent bond; Posttranslational modification; Computational biology; Prolyl isomerase; Biology; Enzyme; Cancer research; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008470395,0.0003885838,0.0002334673,0.0001942654,0.0001376802,0.0002262197,0.0001148593,0.0001637988,0.0008696814],"category_scores_gemma":[0.00006223367,0.0001246814,0.0002182881,0.0001870288,0.0001675401,0.0001260365,0.0001757236,0.0003053804,0.0001805249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001513603,"about_ca_system_score_gemma":0.0001538359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007693706,"about_ca_topic_score_gemma":0.001224525,"domain_scores_codex":[0.9998969,0.000008357887,0.000007883743,0.00002383408,0.00003944887,0.00002364977],"domain_scores_gemma":[0.9999592,0.000005454555,0.00001662569,0.000003826996,0.000004902562,0.00001006247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001023862,0.000009859043,0.000173965,0.00002484262,0.000005167058,0.00002438464,0.000008149353,0.00003124488,0.998907,0.00001531007,0.00002101595,0.0006767568],"study_design_scores_gemma":[0.000005082642,0.0001946553,0.00925845,0.000003098636,0.00001289971,0.0001090921,0.00003390159,0.0003625519,0.9887183,0.00001464207,0.001284162,0.000003183453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946242,0.002306333,0.001175939,0.00007301238,0.00002848488,0.00001707647,0.0007803823,0.0000540379,0.0009404566],"genre_scores_gemma":[0.9936064,0.001616413,0.001230592,0.00007184153,0.000008298918,0.0000277677,0.001283153,0.00001587956,0.002139506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008696814,"threshold_uncertainty_score":0.002909422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008089386624383823,"score_gpt":0.2582599983734384,"score_spread":0.2501706117490546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}