{"id":"W4411572632","doi":"10.1016/j.jpeds.2025.114701","title":"Testing Higher Doses of Sildenafil to Repair Brain Injury Secondary to Birth Asphyxia: An Open-Label Dose-Finding Phase 1b Clinical Trial–Sildenafil Administration to Treat Neonatal Encephalopathy–Study 02","year":2025,"lang":"en","type":"article","venue":"The Journal of Pediatrics","topic":"Neonatal and fetal brain pathology","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Philips (Canada); Centre Hospitalier Universitaire Sainte-Justine; McGill University; Université de Montréal; McGill University Health Centre","funders":"Faculté de médecine et des sciences de la santé, Université de Sherbrooke; Faculty of Medicine and Health, University of Sydney; Canadian Institutes of Health Research; Institute of Human Development, Child and Youth Health; Courtois Foundation; Fondation de l'Hôpital de Montréal pour enfants; Children's Hospital Foundation; McGill University; Faculty of Medicine, McGill University; Pfizer","keywords":"Medicine; Sildenafil; Asphyxia; Clinical trial; Anesthesia; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001308583,0.001559859,0.002275142,0.0003092478,0.0003977756,0.001107207,0.0008109934,0.001980215,0.006620402],"category_scores_gemma":[0.001349717,0.0004772832,0.002287268,0.0002406608,0.0007634003,0.0008876502,0.000213753,0.003596537,0.0009804005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006909497,"about_ca_system_score_gemma":0.001188831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001088859,"about_ca_topic_score_gemma":0.002902189,"domain_scores_codex":[0.9996026,0.0001885468,0.00003048493,0.00009006753,0.00003008693,0.0000582516],"domain_scores_gemma":[0.9992558,0.0002414992,0.0001370795,0.00006469905,0.00006208858,0.000238738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8842438,0.04165214,0.001488749,0.001487306,0.002419011,0.0001756789,0.0001671904,0.0008664916,0.02240081,0.0003397361,0.003156359,0.04160274],"study_design_scores_gemma":[0.7632082,0.2294818,0.003012879,0.00005516791,0.0005706106,0.00009326154,0.00005173371,0.0005055566,0.001684003,0.0001722256,0.001137492,0.00002708284],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884087,0.002990238,0.0006803483,0.001132889,0.0004543762,0.002378741,0.001647414,0.0001272814,0.002180056],"genre_scores_gemma":[0.9783392,0.004841929,0.002908846,0.002442829,0.0005968948,0.003468586,0.002257687,0.0000568445,0.005087131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006620402,"threshold_uncertainty_score":0.02214748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1057961285556695,"score_gpt":0.4371446815592908,"score_spread":0.3313485530036212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}