{"id":"W4411573839","doi":"10.1016/j.expneurol.2025.115361","title":"Sex-specific proteomic analysis of epileptic brain tissues from Pten knockout mice and human refractory epilepsy","year":2025,"lang":"en","type":"article","venue":"Experimental Neurology","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Southern Methodist University; Saint Mary’s University","keywords":"Epilepsy; KEGG; PTEN; Cortical dysplasia; Knockout mouse; Biology; Medicine; Proteome; Bioinformatics; Neuroscience; Gene; Genetics; Gene expression; Transcriptome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":{"n_in":0,"stratum":"fund_new","weight":1678.9,"opus":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Proteomic analysis of epileptic brain tissue; a biomedical mechanism question."},"gpt":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"The study analyzes sex-specific proteomic differences in epilepsy."},"grok":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Sex-specific proteomics of epileptic tissue is biomedical disease research, not metaresearch."}},"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000188209,0.0003266849,0.0002107437,0.0009886571,0.0001660798,0.0002356116,0.0001487799,0.0002101063,0.001286959],"category_scores_gemma":[0.0001683958,0.0001357559,0.0002601986,0.0004092613,0.0002393731,0.0001679611,0.000258955,0.000238764,0.0002878321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009269651,"about_ca_system_score_gemma":0.000104038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003245194,"about_ca_topic_score_gemma":0.0004725415,"domain_scores_codex":[0.9998758,0.000009917704,0.0000191552,0.00003919806,0.00003599882,0.00001988242],"domain_scores_gemma":[0.9998816,0.00001409752,0.00005540628,0.000010939,0.00001445212,0.00002346273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003245763,0.00002426803,0.007071819,0.00005271291,0.00002820623,0.0004503836,0.00004330355,0.00003395601,0.9899984,0.00004650935,0.00007604266,0.001849884],"study_design_scores_gemma":[0.00003769013,0.000657731,0.4742499,0.0000246626,0.0001331583,0.01171103,0.0002700285,0.0006080024,0.508867,0.0002378594,0.003184499,0.00001844845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946733,0.0007451385,0.001774278,0.00006613509,0.00001304837,0.00002860367,0.001992282,0.00005805596,0.0006491823],"genre_scores_gemma":[0.9912867,0.001029343,0.002938889,0.00009056401,0.000009778581,0.00007606519,0.003454002,0.00003361616,0.001080987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001286959,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01172426000447701,"score_gpt":0.3031640018024329,"score_spread":0.2914397417979558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}