{"id":"W4411580395","doi":"10.1128/aac.00054-25","title":"Clinical effectiveness, safety, and viral mutagenicity of oral favipiravir for COVID-19: results from a community-based, open-label, randomized Phase III trial","year":2025,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Chief Scientist Office, Scottish Government Health and Social Care Directorate; Cancer Research UK; Scottish Government Health and Social Care Directorate","keywords":"Favipiravir; Coronavirus disease 2019 (COVID-19); Randomized controlled trial; Open label; Medicine; Clinical trial; 2019-20 coronavirus outbreak; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Pandemic; Pharmacology; Internal medicine; Outbreak; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004668237,0.001667428,0.002610298,0.0003657343,0.0006266062,0.001445906,0.001118283,0.002328991,0.006430963],"category_scores_gemma":[0.004064272,0.0005987244,0.002368032,0.0004862449,0.001446262,0.001263604,0.0004632836,0.003347492,0.001041308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009069593,"about_ca_system_score_gemma":0.001584776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009670615,"about_ca_topic_score_gemma":0.002111967,"domain_scores_codex":[0.99761,0.001523541,0.0001763872,0.0002639867,0.0001824339,0.0002437063],"domain_scores_gemma":[0.99674,0.0009910753,0.0007664783,0.0002336876,0.0002942032,0.0009745139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9607394,0.01817493,0.001139286,0.0005673719,0.001114649,0.00003744829,0.00008129696,0.0002128929,0.003354931,0.00006377932,0.0007526255,0.01376147],"study_design_scores_gemma":[0.873376,0.1220249,0.002821042,0.00004319069,0.0005504099,0.00003126034,0.00002951943,0.0002135159,0.0003998608,0.00009805002,0.0003969402,0.00001520446],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98204,0.003295246,0.0007504817,0.0006772472,0.0003335326,0.008894126,0.001807032,0.00009352262,0.002108866],"genre_scores_gemma":[0.9834056,0.001850651,0.002457028,0.001109334,0.000519553,0.006968931,0.001837114,0.00003598065,0.001815781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006430963,"threshold_uncertainty_score":0.0246883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1004997558542522,"score_gpt":0.4610655514188666,"score_spread":0.3605657955646145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}