{"id":"W4411581370","doi":"10.1016/j.xcrm.2025.102202","title":"Targeting synthetic lethality between non-homologous end joining and radiation in very-high-risk medulloblastoma","year":2025,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children; McGill University; Montreal Clinical Research Institute; SickKids Foundation; University of Toronto; Ontario Institute for Cancer Research","funders":"Canada Research Chairs; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Fondation De Famille Alvin Segal; Terry Fox Research Institute; Health Canada; Ontario Ministry of Health and Long-Term Care; Canadian Cancer Society; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Princess Margaret Cancer Foundation; Garron Family Cancer Centre; Rally Foundation","keywords":"Lethality; Medulloblastoma; Homologous chromosome; Synthetic lethality; Homologous recombination; Non-homologous end joining; Medicine; Biology; Cancer research; Genetics; DNA repair; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003136419,0.0003597757,0.0004212864,0.0003565791,0.0001549531,0.000449953,0.0003455224,0.0003516496,0.001587425],"category_scores_gemma":[0.000191939,0.0001562306,0.0002970188,0.0001415205,0.0003807355,0.0002500206,0.0004487312,0.0006283143,0.0002898633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002998395,"about_ca_system_score_gemma":0.0002526763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003939126,"about_ca_topic_score_gemma":0.0009931541,"domain_scores_codex":[0.9997064,0.00005842379,0.00002264538,0.00005449239,0.0001060243,0.00005194972],"domain_scores_gemma":[0.9998872,0.00002723027,0.00003646413,0.00001487813,0.000005790565,0.00002829851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002517616,0.0001370525,0.0007064128,0.00009449265,0.00003290441,0.000165424,0.000018064,0.0004525727,0.99147,0.0004557739,0.0001343625,0.006081235],"study_design_scores_gemma":[0.00004012113,0.001495917,0.004098626,0.00001468112,0.00004702545,0.001464199,0.00003357496,0.001768497,0.98721,0.0001943183,0.003620712,0.00001220902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832624,0.002963239,0.01009153,0.0001857113,0.00005374326,0.0001008827,0.000288445,0.0002841243,0.00276975],"genre_scores_gemma":[0.9955451,0.0008867325,0.002340777,0.00004374814,0.000006686957,0.00002896571,0.0002331803,0.0000241293,0.0008905868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001587425,"threshold_uncertainty_score":0.005310476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00733500892525055,"score_gpt":0.2566258022556837,"score_spread":0.2492907933304331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}