{"id":"W4411590237","doi":"10.1101/2025.06.23.661037","title":"Microenvironmental TGF-β is an early driver of NF1-associated tumour formation","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Cancer Research UK; Bloomberg Philanthropies; Neurofibromatosis Therapeutic Acceleration Program; Johns Hopkins University","keywords":"Transforming growth factor; Cancer research; Business; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001096447,0.0001416328,0.0001048602,0.0002448918,0.0001135745,0.0002357516,0.00008750433,0.0002255305,0.002786502],"category_scores_gemma":[0.0001161662,0.0000717685,0.0001091256,0.0001020942,0.0001760102,0.0001192573,0.0001390007,0.0004345808,0.0007024884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001565468,"about_ca_system_score_gemma":0.000101236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004811122,"about_ca_topic_score_gemma":0.0005443344,"domain_scores_codex":[0.9999397,0.00000903959,0.000004614576,0.00001212575,0.00002015099,0.00001436565],"domain_scores_gemma":[0.9999305,0.00001544125,0.00001801694,0.000007402492,0.000008718897,0.00001996691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001860804,0.00002408299,0.005104937,0.00004666014,0.000005752888,0.0009831206,0.00005841982,0.0000644619,0.9895011,0.0003198455,0.0001972649,0.003508244],"study_design_scores_gemma":[0.00001997502,0.0002038424,0.06702628,0.00002013479,0.00002662237,0.01279604,0.0002580111,0.0009969214,0.9026855,0.0005873972,0.01537116,0.000008120046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911374,0.001923239,0.001786532,0.0001688176,0.00004019632,0.00001807524,0.0002778483,0.0000698106,0.00457818],"genre_scores_gemma":[0.9943909,0.0007257828,0.001213898,0.00003124337,0.0000155864,0.00001244571,0.0003317887,0.00001240464,0.003266088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002786502,"threshold_uncertainty_score":0.009321749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01532617821156892,"score_gpt":0.2240750396463658,"score_spread":0.2087488614347968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}