{"id":"W4411609441","doi":"10.1021/acsomega.5c02356","title":"From Lab to Clinical Application: Establishing a “Gold” Touchstone for Lung Cancer Biomarker-CEA to Advance Diagnostic","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Biosensors and Analytical Detection","field":"Engineering","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"123 Certification (Canada)","funders":"Fundamental Research Funds for the Central Universities","keywords":"Lung cancer; Biomarker; Medicine; Gold standard (test); Cancer; Oncology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006551752,0.0006867681,0.0007257665,0.0009198257,0.0004457235,0.004254375,0.0009825733,0.002220836,0.00309412],"category_scores_gemma":[0.006239026,0.000544031,0.00047243,0.000458304,0.002622874,0.002971319,0.002611674,0.002951138,0.002617413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00122544,"about_ca_system_score_gemma":0.003476615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005255428,"about_ca_topic_score_gemma":0.0008286064,"domain_scores_codex":[0.9949965,0.001813963,0.0003767905,0.0008690928,0.001609725,0.0003339161],"domain_scores_gemma":[0.9968407,0.001126115,0.0002439758,0.000420211,0.0007883014,0.0005806957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006474357,0.0005724416,0.004995818,0.001349577,0.0001020412,0.0007423545,0.0008701251,0.001166207,0.5203784,0.03185042,0.01174989,0.4255753],"study_design_scores_gemma":[0.0002400559,0.005936069,0.009000729,0.001059579,0.0002183998,0.003058609,0.001360309,0.008847721,0.6444508,0.0419796,0.2836058,0.0002422623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1845508,0.1073389,0.5200322,0.1299055,0.0057227,0.001629311,0.0005729362,0.004247492,0.04600013],"genre_scores_gemma":[0.6034586,0.02335067,0.3173604,0.04042191,0.001946935,0.0004972971,0.0003061306,0.0004849658,0.01217308],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006551752,"threshold_uncertainty_score":0.03464943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01166246017471774,"score_gpt":0.3207955427130172,"score_spread":0.3091330825382995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}