{"id":"W4411615217","doi":"10.1101/2025.06.16.25329734","title":"Diagnostic Criteria and Disease Staging for Desmoplakin Cardiomyopathy","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Cardiovascular Effects of Exercise","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"Baugarten Stiftung; Johns Hopkins University","keywords":"Desmoplakin; Cardiomyopathy; Medicine; Disease; Internal medicine; Cardiology; Heart failure; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008331656,0.0004070384,0.001076391,0.0002795646,0.00008503786,0.00008578427,0.0001707802,0.0002018627,0.00001844819],"category_scores_gemma":[0.006166412,0.0003993105,0.0007834203,0.0001058721,0.0001001047,0.00004141089,0.0006730777,0.0004072715,0.000005816218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001016148,"about_ca_system_score_gemma":0.0004072184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004033045,"about_ca_topic_score_gemma":0.000002551245,"domain_scores_codex":[0.9980015,0.0001294717,0.000318713,0.0008520427,0.0003273541,0.0003709849],"domain_scores_gemma":[0.9970802,0.000938045,0.00008049205,0.001204885,0.0001815008,0.0005148828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002163175,0.0003241573,0.8955499,0.03865642,0.002844365,0.003956372,0.0005997776,0.0003253931,0.0007821257,0.0003554134,0.01471479,0.03972813],"study_design_scores_gemma":[0.005281768,0.0001511097,0.9388502,0.009625903,0.01030194,0.00007127604,0.00004670909,0.002778544,0.0009020846,0.00354176,0.02731927,0.00112949],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654315,0.01674326,0.009757048,0.001279283,0.001705718,0.003790767,0.0005163121,0.0002021716,0.0005739122],"genre_scores_gemma":[0.9935991,0.0009838043,0.002293666,0.0003983906,0.0006994094,0.001215631,0.0002735755,0.00006673689,0.000469641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04330026,"threshold_uncertainty_score":0.9998459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01567731918540683,"score_gpt":0.3046821141605419,"score_spread":0.2890047949751351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}