{"id":"W4411619024","doi":"10.1038/s41398-025-03425-0","title":"Elevated plasma GDF15 combined with FGF21 suggests mitochondrial dysfunction in a subgroup of anorexia nervosa patients","year":2025,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Mental Health; U.S. Department of Health and Human Services; Lundbeckfonden; Vetenskapsrådet; Karolinska Institutet; Hjärnfonden","keywords":"GDF15; Anorexia nervosa; Internal medicine; FGF21; Endocrinology; Anorexia; Lean body mass; Cachexia; Medicine; Cancer; Eating disorders; Psychiatry; Fibroblast growth factor; Body weight; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007806867,0.0001807511,0.0002894695,0.0003499045,0.00004704028,0.000006544542,0.00006582403,0.0002288093,0.0001022782],"category_scores_gemma":[0.00001161348,0.0001432699,0.00009822621,0.0008136645,0.00008828638,0.00007733791,0.000005138885,0.0002508836,0.000008139047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003181707,"about_ca_system_score_gemma":0.0003285586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004752875,"about_ca_topic_score_gemma":0.0003730358,"domain_scores_codex":[0.998658,0.00004920016,0.0004637346,0.000279097,0.0003503349,0.0001996368],"domain_scores_gemma":[0.9994631,0.0000529447,0.0001009313,0.0001714864,0.0001437524,0.00006781396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01340889,0.0009551218,0.9795534,0.000190562,0.0002377976,0.00000296227,0.0001003107,0.0001304646,0.00184891,0.001347994,0.001436019,0.0007875972],"study_design_scores_gemma":[0.02100798,0.0007707633,0.975408,0.000439378,0.000173298,0.000004576974,0.00003959682,0.0009012245,0.0001708232,0.0007285359,0.0002155519,0.0001402951],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924235,0.000124406,0.0001956535,0.002241025,0.001162441,0.0006663253,0.0000256127,0.00004480517,0.003116204],"genre_scores_gemma":[0.9968916,0.000008660521,0.002073482,0.0001583323,0.00006085627,0.00001524077,0.0004433886,0.00001679815,0.0003317037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007599087,"threshold_uncertainty_score":0.5842378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004797835019528294,"score_gpt":0.2266432691336261,"score_spread":0.2218454341140978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}