{"id":"W4411620897","doi":"10.1038/s41467-025-60793-3","title":"Prion-induced ferroptosis is facilitated by RAC3","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Università degli Studi di Verona; Deutsche Forschungsgemeinschaft","keywords":"Programmed cell death; Reactive oxygen species; Oxidative stress; Lipid peroxidation; Neurodegeneration; Cell biology; Prion protein; GPX4; Cell; Biology; Protein aggregation; Chemistry; Disease; Apoptosis; Biochemistry; Medicine; Superoxide dismutase; Glutathione peroxidase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001025515,0.0002149302,0.0001081538,0.0001407345,0.000249858,0.0002386659,0.0001510559,0.0002313805,0.0008336465],"category_scores_gemma":[0.00009657764,0.00009349504,0.0001807881,0.00006484253,0.0001945642,0.0001073108,0.0001919736,0.00033404,0.0003548602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002357264,"about_ca_system_score_gemma":0.000139757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004812007,"about_ca_topic_score_gemma":0.0004818235,"domain_scores_codex":[0.9999223,0.00001779777,0.000005624055,0.00001509573,0.00001926999,0.00001992849],"domain_scores_gemma":[0.9998909,0.00001885039,0.0000332399,0.000012994,0.00001877661,0.00002514419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008823628,0.00001019173,0.0001538263,0.00001290493,0.000002114082,0.00006311396,0.00000740821,0.00002569289,0.9991543,0.0001124284,0.00003902417,0.0003306588],"study_design_scores_gemma":[0.00004906087,0.0002028221,0.01049952,0.00001053482,0.0000146685,0.0009876554,0.00003883019,0.003676636,0.9806007,0.0003715309,0.003539655,0.000008496557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960415,0.0007361936,0.001794596,0.0001492454,0.00001877033,0.00001132604,0.0001196497,0.00006863257,0.001059987],"genre_scores_gemma":[0.9977319,0.0002459133,0.0009744213,0.00003871447,0.000005633564,0.000009424102,0.0001588486,0.00000943234,0.0008258374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008336465,"threshold_uncertainty_score":0.002788901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01202493692717869,"score_gpt":0.3184822797307501,"score_spread":0.3064573428035713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}