{"id":"W4411621161","doi":"10.1007/s00262-025-04105-0","title":"Intratumoral IL12 mRNA administration activates innate and adaptive pathways in checkpoint inhibitor-resistant tumors resulting in complete responses","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute","keywords":"Tumor microenvironment; Immune system; Cancer research; Melanoma; Immunotherapy; Cytotoxic T cell; Chemokine; Acquired immune system; Interleukin 12; Cancer; Immunology; Cancer immunotherapy; Biology; Medicine; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007641743,0.0004340329,0.0008099455,0.000980399,0.0001651621,0.00005922873,0.0002149607,0.0003024258,0.00009392519],"category_scores_gemma":[0.0001085927,0.0004131929,0.0001302278,0.001198493,0.0006282615,0.0002321668,0.00007007524,0.0007965362,0.000002388721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009095827,"about_ca_system_score_gemma":0.0008828528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00183353,"about_ca_topic_score_gemma":0.001030812,"domain_scores_codex":[0.9970994,0.0003498411,0.00107905,0.0006588138,0.0001833232,0.0006295497],"domain_scores_gemma":[0.9987804,0.0002573397,0.0003152102,0.0004732034,0.0001263945,0.00004739673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0786932,0.000234441,0.01584849,0.00005882744,0.0003253712,0.000128845,0.001662176,0.000003856056,0.8531828,0.0004874348,0.00006715326,0.04930739],"study_design_scores_gemma":[0.01532834,0.001562476,0.7857646,0.00200276,0.0000271604,0.00006406214,0.002061248,0.0001398913,0.1874356,0.0004992322,0.004636222,0.000478419],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613868,0.03264972,0.00002064268,0.004009868,0.000450304,0.000730163,0.00005717537,0.00008075228,0.0006146068],"genre_scores_gemma":[0.9917279,0.005971935,0.000293813,0.001089084,0.00005331938,0.0003182795,0.00003434681,0.00004475721,0.0004665393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7699161,"threshold_uncertainty_score":0.999832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03074365858966397,"score_gpt":0.302245940914051,"score_spread":0.2715022823243871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}