{"id":"W4411624526","doi":"10.3390/curroncol32070370","title":"Unveiling ctDNA Response: Immune Checkpoint Blockade Therapy in a Patient with POLE Mutation-Associated Early-Onset Colon Cancer","year":2025,"lang":"en","type":"article","venue":"Current Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Arizona","keywords":"Colorectal cancer; Medicine; Immune checkpoint; Cancer; Malignancy; Blockade; Cancer research; Incidence (geometry); Microsatellite instability; Oncology; Internal medicine; Immunotherapy; Genetics; Biology; Gene; Receptor; Allele","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001468348,0.000346699,0.0007323414,0.0006060986,0.0009878912,0.0006038023,0.0003419713,0.001963428,0.001368919],"category_scores_gemma":[0.000780198,0.0001748934,0.0004469438,0.0003701965,0.0003806875,0.0006513793,0.0003112559,0.002261663,0.0004070173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009994541,"about_ca_system_score_gemma":0.0006014617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002367339,"about_ca_topic_score_gemma":0.004280285,"domain_scores_codex":[0.9998713,0.00001562252,0.0000139493,0.00003442191,0.00002154649,0.00004321351],"domain_scores_gemma":[0.9996979,0.00005431376,0.00002775766,0.000009891308,0.00003488105,0.0001752427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.001586907,0.0004668062,0.04604426,0.0002265696,0.00005965617,0.9052777,0.0005261504,0.0009755932,0.009079142,0.0006761712,0.004899798,0.03018129],"study_design_scores_gemma":[0.0001973982,0.002510026,0.05477209,0.0002110149,0.0001456331,0.920721,0.0004804629,0.0042984,0.00458487,0.00171509,0.01029667,0.00006726008],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9316908,0.01750034,0.00331526,0.02735918,0.001045676,0.0002742107,0.0007439745,0.0002352245,0.01783522],"genre_scores_gemma":[0.9887959,0.002310714,0.001157802,0.004703954,0.0003627577,0.00002374173,0.00025853,0.00002702227,0.002359511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002367339,"threshold_uncertainty_score":0.007251561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02225566923279777,"score_gpt":0.3423823332940116,"score_spread":0.3201266640612139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}