{"id":"W4411627913","doi":"10.1001/jamadermatol.2025.1849","title":"Guselkumab for Moderate to Severe Scalp Psoriasis Across All Skin Tones","year":2025,"lang":"en","type":"article","venue":"JAMA Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lynde Centre for Dermatology; University of Toronto; University of British Columbia","funders":"LEO Pharma; Glenmark Pharmaceuticals; Incyte; Kiniksa Pharmaceuticals; Dermira; Sun Pharma; Regeneron Pharmaceuticals; L'Oreal USA; Sanofi; Amgen; Pfizer; Galderma; Ortho Dermatologics; Eli Lilly and Company; Bristol-Myers Squibb; Biogen; GlaxoSmithKline","keywords":"Medicine; Scalp; Psoriasis; Dermatology Life Quality Index; Dermatology; Quality of life (healthcare); Adverse effect; Clinical endpoint; Placebo; Randomized controlled trial; Clinical trial; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000157494,0.0003378718,0.0006533874,0.0001829464,0.0003799289,0.00005427249,0.000391044,0.0007184757,0.0001379456],"category_scores_gemma":[0.0001382644,0.0003092104,0.0002278279,0.0002472018,0.0001073661,0.0001240153,0.0001780486,0.0001641391,0.0007670752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000065931,"about_ca_system_score_gemma":0.0001076055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008077665,"about_ca_topic_score_gemma":0.0002057693,"domain_scores_codex":[0.9978807,0.0002297418,0.0004468111,0.0005814001,0.00003078837,0.0008305533],"domain_scores_gemma":[0.9987718,0.0004579696,0.00009772772,0.0004771473,0.000146314,0.00004904179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01060151,0.001115549,0.01050555,0.0003951651,0.005667236,0.0001578306,0.006455589,0.0001583749,0.06263652,0.02948205,0.4655582,0.4072665],"study_design_scores_gemma":[0.01060208,0.0001609002,0.007796115,0.00005624488,0.000378428,0.0006661504,0.0006020576,0.00004140244,0.3438269,0.002324946,0.6329542,0.0005905839],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789075,0.002458127,0.002459222,0.009341229,0.0027821,0.0009045033,0.0003930093,0.0002159653,0.002538393],"genre_scores_gemma":[0.9856642,0.00009141978,0.0008931133,0.003938502,0.00006611042,0.0005618308,0.0003448449,0.00003077862,0.00840919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4066759,"threshold_uncertainty_score":0.999936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01699619466388062,"score_gpt":0.2882473212907813,"score_spread":0.2712511266269007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}