{"id":"W4411627913","doi":"10.1001/jamadermatol.2025.1849","title":"Guselkumab for Moderate to Severe Scalp Psoriasis Across All Skin Tones","year":2025,"lang":"en","type":"article","venue":"JAMA Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lynde Centre for Dermatology; University of Toronto; University of British Columbia","funders":"LEO Pharma; Glenmark Pharmaceuticals; Incyte; Kiniksa Pharmaceuticals; Dermira; Sun Pharma; Regeneron Pharmaceuticals; L'Oreal USA; Sanofi; Amgen; Pfizer; Galderma; Ortho Dermatologics; Eli Lilly and Company; Bristol-Myers Squibb; Biogen; GlaxoSmithKline","keywords":"Medicine; Scalp; Psoriasis; Dermatology Life Quality Index; Dermatology; Quality of life (healthcare); Adverse effect; Clinical endpoint; Placebo; Randomized controlled trial; Clinical trial; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008064612,0.0002521432,0.0004951379,0.0001307073,0.0001957641,0.0003222838,0.0002084188,0.0002903379,0.002954058],"category_scores_gemma":[0.00060794,0.0001330186,0.0005131569,0.0001816284,0.0002058017,0.0002154873,0.0001177584,0.0006668351,0.0002760902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002213491,"about_ca_system_score_gemma":0.0004682013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007131729,"about_ca_topic_score_gemma":0.002837689,"domain_scores_codex":[0.9997811,0.0001116758,0.00001620965,0.00002650091,0.00003138725,0.00003318447],"domain_scores_gemma":[0.9997378,0.00007486674,0.00007784628,0.00001541289,0.00001837448,0.00007576977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.514862,0.01040245,0.05714957,0.002809017,0.002424397,0.0004224147,0.0001532448,0.0007603141,0.05453023,0.0003922453,0.00569691,0.3503972],"study_design_scores_gemma":[0.4585795,0.2602163,0.2533342,0.00039867,0.002258762,0.002236665,0.0002292066,0.001171096,0.00727667,0.0007193896,0.01353211,0.00004739826],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882658,0.007606626,0.0004030545,0.0004611032,0.00009778592,0.0007010861,0.0003995192,0.00004269181,0.002022304],"genre_scores_gemma":[0.9963151,0.001520864,0.0004546888,0.000347825,0.00008174621,0.000242399,0.0002011683,0.000003828919,0.00083243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002954058,"threshold_uncertainty_score":0.009882331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01699619466388062,"score_gpt":0.2882473212907813,"score_spread":0.2712511266269007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}