{"id":"W4411627919","doi":"10.1001/jamadermatol.2025.1836","title":"Guselkumab for Moderate to Severe Psoriasis Across All Skin Tones","year":2025,"lang":"en","type":"article","venue":"JAMA Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Probity Medical Research; University of Toronto","funders":"Sun Pharma; LEO Pharma; Galderma; Incyte; Regeneron Pharmaceuticals; L'Oreal USA; Sanofi; Amgen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Psoriasis; Dermatology Life Quality Index; Psoriasis Area and Severity Index; Randomized controlled trial; Dermatology; Placebo; Adverse effect; Internal medicine; Physical therapy; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001428966,0.0003141934,0.0006060295,0.0001698666,0.0003479802,0.00004851831,0.0003642911,0.0006584589,0.0001339973],"category_scores_gemma":[0.0001293841,0.0002881747,0.0002087005,0.0002254308,0.0000907682,0.0001148523,0.0001606457,0.0001505048,0.0007088526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006009812,"about_ca_system_score_gemma":0.0001025771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007722537,"about_ca_topic_score_gemma":0.0001931777,"domain_scores_codex":[0.998039,0.0002075668,0.0004135392,0.0005384749,0.00002723179,0.0007741749],"domain_scores_gemma":[0.998845,0.0004348216,0.00009175669,0.0004499276,0.0001356963,0.00004282095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0106662,0.001045793,0.009257524,0.0003797869,0.005938292,0.0001594195,0.007553073,0.0001572801,0.06613595,0.03508649,0.5059861,0.3576341],"study_design_scores_gemma":[0.009474147,0.00014124,0.005648554,0.00004335502,0.0003229878,0.0005659399,0.0005753009,0.00002918984,0.3103134,0.002082891,0.6702999,0.0005031443],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789771,0.00244762,0.00234897,0.009177778,0.002823154,0.000881594,0.0003865899,0.0002098548,0.002747291],"genre_scores_gemma":[0.9849135,0.00008963071,0.0008339239,0.003990715,0.00006133818,0.0005575945,0.0003370337,0.00002849268,0.009187774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3571309,"threshold_uncertainty_score":0.999957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01758318802583139,"score_gpt":0.2887633835104765,"score_spread":0.2711801954846451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}