{"id":"W4411634695","doi":"10.1021/acs.orglett.5c02284","title":"Fungal Sulfotransferase from <i>Metarhizium majus</i> Catalyzes the Formation of <i>PPZ</i> Pathway Intermediate Peramine-8-<i>O</i>-sulfate","year":2025,"lang":"en","type":"article","venue":"Organic Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Sulfotransferase; Stereochemistry; Sulfate; Sulfation; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008284822,0.0003496499,0.000152574,0.0001152598,0.00009817727,0.0002008549,0.00008951743,0.0001711206,0.0006786602],"category_scores_gemma":[0.0001069627,0.0001086423,0.0002149314,0.00009776947,0.00009071628,0.0001287326,0.0001608419,0.0002744722,0.0003177516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001900536,"about_ca_system_score_gemma":0.000210983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006152956,"about_ca_topic_score_gemma":0.001053726,"domain_scores_codex":[0.9999357,0.000008496153,0.000005085404,0.00001466364,0.00002126532,0.00001471801],"domain_scores_gemma":[0.9999418,0.000008209947,0.0000203127,0.000005979297,0.000007745878,0.0000159294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001813932,0.000003028036,0.0001836888,0.00001124539,0.000001464159,0.00002223596,0.00000470528,0.00001437276,0.9989759,0.00003238084,0.0000111438,0.0007217571],"study_design_scores_gemma":[0.000003696682,0.00008277435,0.005569458,0.000001819188,0.000006582724,0.0004259426,0.00001972919,0.0002759695,0.9916928,0.00004023994,0.001878501,0.000002585617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882551,0.000874406,0.007356722,0.0001717347,0.00002631764,0.00002945252,0.0007521844,0.0001014309,0.002432699],"genre_scores_gemma":[0.9902717,0.0004634659,0.00519655,0.00003353982,0.000008432485,0.00001077821,0.001673246,0.00001354321,0.002328763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006786602,"threshold_uncertainty_score":0.002270341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006037442171399909,"score_gpt":0.1986722539558591,"score_spread":0.1926348117844592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}