{"id":"W4411639549","doi":"10.1182/blood.2024026735","title":"Clinical and molecular features of immunodeficiency in patients with telomere biology disorders","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute","funders":"","keywords":"Neutropenia; Immunodeficiency; Telomere; Cohort; Internal medicine; Immunology; Medicine; Lymphocyte; Biomarker; Gastroenterology; Biology; Immune system; Chemotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002957706,0.0003999345,0.0003289767,0.0008531334,0.0003546778,0.0004369062,0.0002607832,0.0004280874,0.001873432],"category_scores_gemma":[0.00143946,0.0001637405,0.0001845986,0.0006973077,0.0003343898,0.0003576829,0.0003749789,0.0003724426,0.0002468704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001713399,"about_ca_system_score_gemma":0.0001886882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007404277,"about_ca_topic_score_gemma":0.0006816455,"domain_scores_codex":[0.9998102,0.00002883212,0.00003159668,0.00004808931,0.00003288306,0.0000484284],"domain_scores_gemma":[0.9990786,0.0002177884,0.000352082,0.00002897298,0.00007945477,0.0002431467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007257712,0.000009160746,0.9976693,0.000006160994,0.000006792461,0.0008345235,0.00002776929,0.00003004303,0.0005646434,0.00001329967,0.00004855309,0.0007173137],"study_design_scores_gemma":[0.000009692944,0.0001744347,0.9855381,0.00001391239,0.00001728462,0.01347364,0.0001257508,0.0001740528,0.0002248127,0.00003092072,0.0002133015,0.000004052715],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989856,0.0003180694,0.00006290519,0.0000209041,0.000003221687,0.000009615145,0.0001574395,0.000004100236,0.0004381337],"genre_scores_gemma":[0.9995913,0.00007032961,0.00007727262,0.00001568791,0.000007837724,0.000006997246,0.0001714102,8.133223e-7,0.00005834423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001873432,"threshold_uncertainty_score":0.00626725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004240536297145078,"score_gpt":0.2663074713435084,"score_spread":0.2620669350463633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}