{"id":"W4411666053","doi":"10.1002/alz.70394","title":"Biomarker changes associated with fornix deep brain stimulation in Alzheimer's disease","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; Sunnybrook Health Science Centre; University of Alberta; Health Sciences Centre; Occupational Cancer Research Centre; Hospital for Sick Children; SickKids Foundation; University Health Network; University of Toronto; McGill University; Douglas Mental Health University Institute","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Nursing Research; National Institute on Aging; Social Sciences and Humanities Research Council of Canada; Parkinson Canada; Canadian Institutes of Health Research; National Institutes of Health; Krembil Foundation; Weston Brain Institute","keywords":"Fornix; Deep brain stimulation; Atrophy; Neuroimaging; Medicine; Neuroscience; Alzheimer's disease; Hippocampal formation; Cerebrospinal fluid; Magnetic resonance imaging; Positron emission tomography; Stimulation; Hippocampus; Amyloid (mycology); Neurology; Pathology; Psychology; Disease; Parkinson's disease; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003101616,0.0004512141,0.0004887729,0.0004103092,0.0001617726,0.0004812617,0.0001577971,0.0003422026,0.001222193],"category_scores_gemma":[0.0004177472,0.0001033297,0.0001922774,0.0003472061,0.0002593877,0.0002398848,0.0001417785,0.0002565405,0.0001364003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003500508,"about_ca_system_score_gemma":0.0001781174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001056073,"about_ca_topic_score_gemma":0.001192163,"domain_scores_codex":[0.9999145,0.00001863535,0.00001172086,0.00002355349,0.00002079786,0.0000108855],"domain_scores_gemma":[0.9997883,0.00003250248,0.0001160041,0.00001163869,0.00003300975,0.00001858216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01549851,0.0006947918,0.4338894,0.001491089,0.001331969,0.004563071,0.000570163,0.001303513,0.3314985,0.0003424322,0.001486664,0.2073299],"study_design_scores_gemma":[0.0001080489,0.002868948,0.9589916,0.00007235604,0.0003900978,0.00605077,0.0001564347,0.0004923341,0.02823906,0.0004632944,0.002139632,0.00002733683],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888036,0.008901238,0.0004833576,0.0001326617,0.00002132983,0.00002761733,0.0002267228,0.00003725608,0.001366307],"genre_scores_gemma":[0.9968641,0.001818212,0.000631848,0.00007272792,0.00001785686,0.00001547721,0.0001680294,0.000003774513,0.0004079179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001222193,"threshold_uncertainty_score":0.00408864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03076363662288663,"score_gpt":0.2936122746897459,"score_spread":0.2628486380668593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}