{"id":"W4411666779","doi":"10.1021/acsnano.5c01158","title":"Oral Nanoarmored Live Bacterial Biotherapeutics Bearing Polyphenol-Based Supraparticles Enhance Chemotherapy via Reestablishing Immuno-Oncology-Microbiome Axis","year":2025,"lang":"en","type":"article","venue":"ACS Nano","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Key Research and Development Program of China; Sichuan Province Science and Technology Support Program; State Key Laboratory of Polymer Materials Engineering; Fundamental Research Funds for the Central Universities; Sichuan University; National Natural Science Foundation of China; Key Laboratory of Leather Chemistry and Engineering of Ministry of Education","keywords":"Microbiome; Cancer research; Chemotherapy; Medicine; Oncology; Nanotechnology; Materials science; Internal medicine; Biology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001081078,0.0004624964,0.0006307698,0.0003147195,0.0004382289,0.0004923716,0.0009755762,0.0003258499,0.0007628332],"category_scores_gemma":[0.0001403875,0.0004621827,0.0001585354,0.0009782688,0.000490272,0.0007521451,0.0002306082,0.0002248025,0.000383945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005368515,"about_ca_system_score_gemma":0.0006272348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007075506,"about_ca_topic_score_gemma":0.0001674573,"domain_scores_codex":[0.9964996,0.0003784402,0.0008284078,0.0008637205,0.0003607377,0.0010691],"domain_scores_gemma":[0.9978457,0.0004393944,0.000319819,0.0009943472,0.0002505461,0.0001501658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009019561,0.0004216505,0.0005261368,0.00004459129,0.00006284278,0.00001657686,0.0007997393,0.00006172896,0.985836,0.00007473698,0.0007025466,0.01055145],"study_design_scores_gemma":[0.002561421,0.0003115662,0.000425008,0.0001188724,0.00007004415,0.000006800426,0.0001825602,0.0003392725,0.9863584,0.0002073604,0.00894326,0.0004754014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928601,0.000611065,0.001662441,0.001808861,0.001879303,0.0005687587,0.00006467883,0.0004096526,0.0001351153],"genre_scores_gemma":[0.9886988,0.00005030549,0.00812857,0.002482045,0.0001643819,0.00006328669,0.00003165209,0.00007171062,0.0003092165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01007604,"threshold_uncertainty_score":0.999783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01155397374595782,"score_gpt":0.2675912982102581,"score_spread":0.2560373244643002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}