{"id":"W4411668691","doi":"10.1038/s41563-025-02269-9","title":"Cytoplasmic anillin and Ect2 promote RhoA/myosin II-dependent confined migration and invasion","year":2025,"lang":"en","type":"article","venue":"Nature Materials","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; National Cancer Institute; Government of Canada; National Institutes of Health; University of Alberta; Natural Sciences and Engineering Research Council of Canada","keywords":"RHOA; Cytokinesis; Cytoplasm; Cell biology; Cell migration; Myosin; Midbody; Guanine nucleotide exchange factor; Biology; Cell division; Chemistry; Cell; GTPase; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001095373,0.0002139361,0.0001136365,0.0001473067,0.0001215958,0.0002343668,0.0001300777,0.0001653753,0.001068371],"category_scores_gemma":[0.00009371014,0.0001332889,0.0001456735,0.00006410712,0.00014961,0.0001579083,0.0003906981,0.0002711383,0.0001773671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001398669,"about_ca_system_score_gemma":0.0001335774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003651449,"about_ca_topic_score_gemma":0.000973355,"domain_scores_codex":[0.999889,0.00001750373,0.000005460241,0.00001527296,0.00004292109,0.00002976683],"domain_scores_gemma":[0.9999354,0.00001124627,0.00001486783,0.000004878287,0.000005601054,0.00002799656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003171175,0.000007850842,0.00004696739,0.000009949677,0.000001676435,0.00002133946,0.000004134169,0.00002424536,0.9994287,0.00006349023,0.00001385813,0.0003461383],"study_design_scores_gemma":[0.00002065368,0.0001580304,0.005450125,0.000004088404,0.000007844936,0.0001845669,0.00002770507,0.002075828,0.9898519,0.00005367153,0.002160589,0.00000501603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951513,0.0008503143,0.002429437,0.00004904094,0.00001302981,0.00001031461,0.00003728636,0.00003548523,0.001423771],"genre_scores_gemma":[0.9969146,0.000232839,0.001169777,0.00002173182,0.000005555863,0.00001751254,0.0000761155,0.000007470942,0.001554305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001068371,"threshold_uncertainty_score":0.003574073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003595323112777044,"score_gpt":0.2335323191568777,"score_spread":0.2299369960441006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}