{"id":"W4411675284","doi":"10.1126/sciimmunol.adt9239","title":"A Dock8-dependent mechanosensitive central actin pool maintains T cell shape and protects the nucleus during migration","year":2025,"lang":"en","type":"article","venue":"Science Immunology","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Clinical Research Institute; Institute for Research in Immunology and Cancer; McGill University","funders":"","keywords":"Cell biology; Mechanosensitive channels; Biology; Actin; Cell migration; Cytoskeleton; Cytokinesis; Immune system; Premature aging; Cell; Immunology; Genetics; Cell division","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001992246,0.0001017509,0.00007598698,0.00008452025,0.0004710654,0.00006911575,0.0002228452,0.00008224469,0.00002071531],"category_scores_gemma":[0.0001046281,0.00008049542,0.00003705277,0.000186507,0.0002225641,0.00001217891,0.0002780815,0.000154223,0.000007305334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004987108,"about_ca_system_score_gemma":0.0001548664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009225823,"about_ca_topic_score_gemma":0.0001523798,"domain_scores_codex":[0.9990553,0.00005551795,0.0001225025,0.0003559052,0.00008639146,0.000324403],"domain_scores_gemma":[0.99954,0.00001054733,0.00006141271,0.0002675631,0.00008785257,0.00003258132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004875593,0.00002819653,0.00003974928,0.000003909607,0.00001484607,0.00000265984,0.0001281184,0.000007633716,0.9974108,0.001274375,0.0000201417,0.001020786],"study_design_scores_gemma":[0.000250617,0.0001291014,0.003618351,0.000009908927,0.000008759002,0.00003314663,0.001010125,0.001118227,0.9911774,0.0002866785,0.002270688,0.00008702983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961284,0.0002551833,0.001273374,0.000900846,0.000398151,0.0002965972,0.00000439963,0.00001077705,0.000732223],"genre_scores_gemma":[0.9983585,0.0001920883,0.0000647297,0.0001790742,0.00003377773,0.00002615372,0.00000595506,0.000005537983,0.001134147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00623346,"threshold_uncertainty_score":0.3623102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003302869981495131,"score_gpt":0.219880368825555,"score_spread":0.2165774988440598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}