{"id":"W4411678908","doi":"10.1016/j.bbi.2025.06.035","title":"Peripheral leptin receptor gene network modulates the impact of childhood adversity on mental health disorders","year":2025,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Children's Hospital; University of Toronto; Centre for Addiction and Mental Health; McGill University Health Centre; McGill University; Douglas Mental Health University Institute","funders":"","keywords":"Peripheral; Leptin; Mental health; Gene; Psychology; Receptor; Medicine; Psychiatry; Internal medicine; Genetics; Biology; Obesity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008778847,0.0001390612,0.0001735401,0.00003905123,0.0006658444,0.00002956908,0.0002408287,0.00004107339,0.00009829294],"category_scores_gemma":[0.00008330025,0.00009727426,0.0001328726,0.0002313941,0.0001774601,0.00005995575,0.0001428553,0.0002186122,0.000001431899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006035878,"about_ca_system_score_gemma":0.0000833874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001569176,"about_ca_topic_score_gemma":0.00005680005,"domain_scores_codex":[0.9988803,0.000378895,0.0001729617,0.0001938698,0.000118663,0.0002552556],"domain_scores_gemma":[0.999371,0.0001687528,0.00008805325,0.0003077743,0.000009986771,0.00005445294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001806446,0.002635767,0.3549817,0.00002884246,0.00006149578,0.000002296324,0.004858281,0.001030741,0.1924173,0.0004994779,0.01252258,0.4291551],"study_design_scores_gemma":[0.0005656709,0.0005426243,0.9933857,0.00003054077,0.000007235722,0.000002808308,0.0002694308,0.00009872195,0.004598196,0.00004394902,0.0003607332,0.00009441252],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979054,0.0003280377,0.00001267282,0.0008717711,0.0001454035,0.0004107822,0.0001085395,0.00002415345,0.0001932456],"genre_scores_gemma":[0.9984232,0.0007599109,0.00001679169,0.0004361662,0.00001538301,0.00001349131,0.00001372955,0.000007512694,0.000313863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.638404,"threshold_uncertainty_score":0.5121204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01456539878177059,"score_gpt":0.298205935799458,"score_spread":0.2836405370176874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}