{"id":"W4411689221","doi":"10.1136/jcp-2024-209954","title":"Karyotypic clonal fraction predicts adverse outcome in <i>TP53</i> -mutated myeloid neoplasms: an International <i>TP53</i> investigators Network (iTiN) study","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Pathology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Internal medicine; Karyotype; Myelodysplastic syndromes; Myeloid; Biology; Oncology; Myeloid leukemia; Proportional hazards model; Allele; Somatic evolution in cancer; Immunology; Medicine; Chromosome; Genetics; Cancer; Bone marrow; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009253148,0.0003108747,0.0002323173,0.0004030354,0.0002296637,0.0004974005,0.0002633315,0.0002935776,0.0007779407],"category_scores_gemma":[0.00144899,0.0001444399,0.0002916986,0.000397232,0.0002279826,0.0002409822,0.0003254929,0.000286004,0.0001501581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001896064,"about_ca_system_score_gemma":0.0001630825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009712647,"about_ca_topic_score_gemma":0.001298041,"domain_scores_codex":[0.9998177,0.00006612091,0.00001533743,0.00005002843,0.00002610419,0.00002468009],"domain_scores_gemma":[0.9990398,0.0002064928,0.0003556978,0.0001070738,0.00006782202,0.0002231027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001161205,0.00003434281,0.9961343,0.000005338207,0.00006963933,0.00005061394,0.00002419322,0.00006288977,0.0005125642,0.00001181429,0.00008148544,0.001851537],"study_design_scores_gemma":[0.00006901465,0.0005232525,0.9979625,0.000005848854,0.0001641658,0.0003066225,0.000059087,0.0004562392,0.0001879028,0.00003508011,0.0002259365,0.000004303435],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999551,0.0001050261,0.00004469756,0.00001700458,0.00000251914,0.000004204411,0.0001017714,0.000001071696,0.0001727799],"genre_scores_gemma":[0.9996006,0.00004928985,0.00004553226,0.000013316,0.00001425248,0.000003372281,0.0002215789,0.000001172687,0.00005075884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009712647,"threshold_uncertainty_score":0.004893601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06236960584833422,"score_gpt":0.4365306258704951,"score_spread":0.3741610200221609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}