{"id":"W4411696543","doi":"10.1080/15592294.2025.2523191","title":"<i>PIK3R1</i> and <i>G0S2</i> are human placenta-specific imprinted genes associated with germline-inherited maternal DNA methylation","year":2025,"lang":"en","type":"article","venue":"Epigenetics","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"Biotechnology and Biological Sciences Research Council; Fondation ARC pour la Recherche sur le Cancer; Medical Research Council; Ministerio de Economía y Competitividad; European Commission; Wellcome Trust","keywords":"Genomic imprinting; Biology; Imprinting (psychology); Differentially methylated regions; DNA methylation; Reprogramming; Epigenetics; Methylation; Genetics; Placenta; Germline; Gene; Gene expression; Fetus; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001174067,0.0002738872,0.0003335054,0.0003585754,0.0002032083,0.0003840262,0.0001798067,0.0001869144,0.001757871],"category_scores_gemma":[0.0003208729,0.000164023,0.0003293256,0.0006583589,0.0002311308,0.0001192726,0.0002923186,0.0002802598,0.0006386647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000340453,"about_ca_system_score_gemma":0.000289938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00339632,"about_ca_topic_score_gemma":0.004554367,"domain_scores_codex":[0.9998589,0.000008906656,0.000008259886,0.00006180569,0.00003600937,0.00002614663],"domain_scores_gemma":[0.9998772,0.00002103008,0.00005744604,0.0000129796,0.0000129052,0.00001847422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009222011,0.00001676892,0.04910502,0.0004466328,0.0002062819,0.0004568496,0.000160577,0.0006908674,0.9133956,0.0005278133,0.001882137,0.03218928],"study_design_scores_gemma":[0.00006482537,0.0002096301,0.6233031,0.00006357214,0.0003391536,0.003006652,0.0001576759,0.003546845,0.3430078,0.0009910022,0.02525238,0.00005741555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.963777,0.00652891,0.006384006,0.0001872427,0.00004248076,0.00005545885,0.01807581,0.001013979,0.003934996],"genre_scores_gemma":[0.979755,0.00161719,0.00438242,0.0001490228,0.00001044076,0.0000362696,0.01210593,0.00009896357,0.001844828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00339632,"threshold_uncertainty_score":0.006753147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077739200060617,"score_gpt":0.2437274359088428,"score_spread":0.2329500439082366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}