{"id":"W4411697281","doi":"10.3390/curroncol32070373","title":"Role of Circulating Tumor DNA in Adapting Immunotherapy Approaches in Breast Cancer","year":2025,"lang":"en","type":"review","venue":"Current Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Taiho Pharmaceutical; Seagen; Gilead Sciences; Sanofi; Pfizer; AstraZeneca; Daiichi Sankyo Europe; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Immunotherapy; Breast cancer; Oncology; Biomarker; Internal medicine; Cancer; Cancer immunotherapy; Metastatic breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001094525,0.0006210763,0.001292944,0.001839033,0.0002285705,0.001118966,0.0008242819,0.001367603,0.002208954],"category_scores_gemma":[0.001467429,0.0002730502,0.0005927574,0.001324233,0.0006159137,0.00142446,0.000717163,0.002233903,0.001310225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007471759,"about_ca_system_score_gemma":0.001218677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009121951,"about_ca_topic_score_gemma":0.001464751,"domain_scores_codex":[0.9997037,0.00008584155,0.0000399726,0.00004398203,0.0001014002,0.00002516114],"domain_scores_gemma":[0.9993569,0.0004306203,0.00005218559,0.00001608386,0.0001155655,0.00002861627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006151292,0.00005149174,0.0001992628,0.01236397,0.00008177937,0.0001668253,0.00006228291,0.0004512297,0.001241516,0.00566466,0.01556708,0.9640884],"study_design_scores_gemma":[0.00002092358,0.0001234471,0.0007363796,0.004391523,0.0001009757,0.001221707,0.00006409433,0.0001657731,0.0006306974,0.003345679,0.9891772,0.00002160506],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008158064,0.9985476,0.0001641535,0.0003954998,0.0002044132,0.000003927049,0.000008883632,0.000005286155,0.0005886159],"genre_scores_gemma":[0.000675432,0.9983172,0.0002335813,0.0003018422,0.0001547215,0.000007881023,0.00001695132,0.000001478698,0.0002908721],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002208954,"threshold_uncertainty_score":0.007389665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09853992681984133,"score_gpt":0.3877431232835384,"score_spread":0.2892031964636971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}