{"id":"W4411698236","doi":"10.3390/jcm14134509","title":"Recombinant IgG1 Fc-μTP-L309C Ameliorates Endogenous Rheumatoid Arthritis in the K/BxN Mouse Model by Decreasing Th1 and Th17 Cells in the Spleen, Lymph Nodes and Joint and Increasing T Regulatory Cells and IL-10 in the Joint","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Medicine","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Toronto","funders":"Canadian Blood Services; CSL Behring","keywords":"FOXP3; Medicine; Arthritis; Synovial fluid; Rheumatoid arthritis; Immunology; Spleen; IL-2 receptor; Inflammatory arthritis; Flow cytometry; T cell; Molecular biology; Cancer research; Immune system; Pathology; Biology; Osteoarthritis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001822901,0.0006657921,0.0004298997,0.0004206115,0.0001978657,0.0001892852,0.0003114711,0.0004725861,0.002509212],"category_scores_gemma":[0.00006283142,0.0001449203,0.0003109607,0.0001910901,0.0003088094,0.0001682602,0.0001164919,0.0008979025,0.0007598042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003918729,"about_ca_system_score_gemma":0.0003175929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001289665,"about_ca_topic_score_gemma":0.001473514,"domain_scores_codex":[0.9997748,0.00002014356,0.00002324473,0.00004339492,0.00007286143,0.00006563988],"domain_scores_gemma":[0.9998721,0.000006930399,0.00005743813,0.00001234846,0.00001476328,0.0000363999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004096614,0.0001137665,0.0001388724,0.00008490312,0.000007591323,0.00004036582,0.000007258849,0.00006384435,0.9975131,0.00002030753,0.0001104535,0.001489823],"study_design_scores_gemma":[0.0001720629,0.002285074,0.003098684,0.00002178375,0.00004126506,0.0004517359,0.00002070149,0.0004611538,0.9908043,0.00002384111,0.002612893,0.00000651403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906809,0.0030293,0.002803296,0.0003252998,0.0001137577,0.0000792459,0.0008647639,0.0004014025,0.001702123],"genre_scores_gemma":[0.9890083,0.001624926,0.002746074,0.0001522694,0.00004811145,0.00009685535,0.0009083532,0.00003341936,0.005381776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002509212,"threshold_uncertainty_score":0.008394122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07627009449818101,"score_gpt":0.3533845375325715,"score_spread":0.2771144430343905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}