{"id":"W4411729473","doi":"10.58931/cht.2025.4s0469","title":"Advancing BTK Inhibition: Non‑Covalent Bruton Tyrosine Kinase Inhibitors and Their Emerging Role in Canadian Practice","year":2025,"lang":"en","type":"article","venue":"Canadian Hematology Today","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; BC Cancer Agency","funders":"Hebrew University of Jerusalem","keywords":"Bruton's tyrosine kinase; Tyrosine kinase; Covalent bond; Chemistry; Biochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002792784,0.0004973882,0.0005453413,0.001365364,0.001181914,0.002528484,0.001237698,0.001741537,0.0128689],"category_scores_gemma":[0.003757184,0.0001914497,0.0003717728,0.001863864,0.002115503,0.001677907,0.0014038,0.002985878,0.001720048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01521649,"about_ca_system_score_gemma":0.02471162,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.236955,"about_ca_topic_score_gemma":0.428086,"domain_scores_codex":[0.9988441,0.0002096105,0.00006988873,0.00014056,0.0005379274,0.0001977377],"domain_scores_gemma":[0.9968347,0.0004455521,0.000342926,0.00007745872,0.001428837,0.0008705169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005935734,0.0001846141,0.002182103,0.001746778,0.00007156622,0.000641827,0.0003908753,0.0006800143,0.004141327,0.02812381,0.1411533,0.8200901],"study_design_scores_gemma":[0.0001946484,0.0002404488,0.002577016,0.001013921,0.00004879301,0.0007934179,0.000192545,0.0003216168,0.001150377,0.004725205,0.9887077,0.00003439388],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009497758,0.7942796,0.002882314,0.1278362,0.003732305,0.0001027823,0.0004762743,0.0001729278,0.06101986],"genre_scores_gemma":[0.09791652,0.8378612,0.006458947,0.03142668,0.002744126,0.00006701578,0.0006072242,0.00009296875,0.02282524],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.763045,"threshold_uncertainty_score":0.4711516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005584451970101021,"score_gpt":0.2758105374282682,"score_spread":0.2702260854581672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}