{"id":"W4411730241","doi":"10.1016/j.arr.2025.102817","title":"Emerging uncertainty on the anti-aging potential of metformin","year":2025,"lang":"en","type":"review","venue":"Ageing Research Reviews","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Velux Fonden; Velux Stiftung","keywords":"Metformin; Medicine; Observational study; Diabetes mellitus; Type 2 diabetes; Ageing; Population ageing; Type 2 Diabetes Mellitus; Population; Clinical trial; Bioinformatics; Intensive care medicine; Pharmacology; Internal medicine; Biology; Endocrinology; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006544618,0.0003923311,0.001633781,0.0002623611,0.0002578195,0.00006046748,0.001109773,0.0002570506,0.0001137225],"category_scores_gemma":[0.002128471,0.0002303848,0.000963359,0.0007616776,0.000191945,0.000004256853,0.0005090176,0.0007881391,0.00004941956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004708763,"about_ca_system_score_gemma":0.0005450104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004864622,"about_ca_topic_score_gemma":0.00001136992,"domain_scores_codex":[0.9951515,0.002097342,0.0008938863,0.0006577899,0.0005500549,0.000649388],"domain_scores_gemma":[0.9977229,0.0002806378,0.0003887297,0.001308386,0.0002098951,0.00008944741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000002603041,0.00002146137,3.19061e-7,0.01489806,0.0001188508,0.000007382191,0.00001027568,0.000003031117,0.0001090581,0.0001969085,0.01150509,0.9731269],"study_design_scores_gemma":[0.00007379396,0.00004774629,4.818141e-7,0.01868413,0.0002012388,0.00000238404,0.00001787766,0.000002467022,0.0003223064,0.00004551245,0.9804009,0.0002011258],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000537933,0.9964305,0.00005106482,0.00002556839,0.0002939558,0.001499955,0.00003432091,0.000006306683,0.001604528],"genre_scores_gemma":[0.00002374264,0.9973466,0.00005990083,0.0001090301,0.0005968563,0.0003952931,0.0001366173,0.0000410241,0.001290985],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9729258,"threshold_uncertainty_score":0.9394818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09899194159242769,"score_gpt":0.4367679534157247,"score_spread":0.337776011823297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}