{"id":"W4411735566","doi":"10.1177/17407745251350598","title":"Afternoon discussion: Statistical issues in clinical trials conference on dose finding","year":2025,"lang":"en","type":"article","venue":"Clinical Trials","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Clinical Evaluative Sciences; SickKids Foundation; Hospital for Sick Children; Public Health Ontario; University of Toronto","funders":"","keywords":"Clinical trial; Medicine; Medical physics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaresearch","research_integrity"],"category_scores_codex":[0.4026717,0.0008165222,0.01156311,0.0004123985,0.0001679858,0.0003367497,0.001255604,0.001859011,0.003521339],"category_scores_gemma":[0.962074,0.0004876532,0.002267655,0.0008057567,0.001168799,0.0001507006,0.0006011273,0.003006686,0.000545234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001377981,"about_ca_system_score_gemma":0.0007100279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001737537,"about_ca_topic_score_gemma":0.00002687591,"domain_scores_codex":[0.8004543,0.1601764,0.0336531,0.002862778,0.001474498,0.00137887],"domain_scores_gemma":[0.1041972,0.8880066,0.004165207,0.002306563,0.0003889646,0.000935475],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.006382247,0.002553108,0.005182022,0.0002004468,0.0004134284,0.0001398512,0.00003780703,0.000001331728,0.0000292056,0.5286837,0.04263294,0.4137439],"study_design_scores_gemma":[0.01298059,0.001143949,0.01195533,0.001866878,0.0006552589,0.000001287877,0.0001079494,0.0005108332,0.0001343682,0.9593471,0.01068863,0.0006078326],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.06790112,0.0007430345,0.7085162,0.0909717,0.06652648,0.02176213,0.003262359,0.001531082,0.03878586],"genre_scores_gemma":[0.1710578,0.002544492,0.7995753,0.004999907,0.009256136,0.0007946573,0.00004431263,0.0002124339,0.01151492],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.7278301,"threshold_uncertainty_score":0.9997575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.9141793752863242,"score_gpt":0.7548013895193272,"score_spread":0.159377985766997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}